FIGURE 1. Profile of AnxA1 protein expression in human PMN.
Resting PMN (A) or PMN stimulated with 10 ng/ml TNF-α (B) were processed for whole lysate (WL), cytosolic (CYT), and membrane (MEM) fractions and immunoblotted with anti-AnxA1 or anti-actin antibody (upper and lower panels, respectively). C, conditioned medium from resting or TNF-α-stimulated PMN was collected and immunoblotted for AnxA1. D, intact and activated PMN (upper and lower panels, respectively) were washed consecutively twice (E1, E2) with 1 mm EDTA to elute membrane-bound AnxA1.