Figure 4.
Maps of genetic influences on white matter integrity. These maps show how different factors, genetic or environmental, explain different proportions of the observed variance in white matter integrity across 92 subjects. The Montreal Neurological Institute (MNI) coordinate (which is also the coordinate used in the ICBM space; expressed in mm) of the slices is indicated at the beginning of each row. The first column shows the statistical significance of the genetic influences (p(A), FDR-adjusted), and the proportional contributions to the overall variance in FA, from genetic (a2), shared environmental (c2) and unique environmental (e2) factors (the second to the last columns, computed under the best-fitting statistical model). The genetic effect is detected in the genu and the splenium of the corpus callosum (x = 0), the right cerebral peduncle, and right ILF/IFO (z = −14), the anterior limbs of the internal capsule bilaterally, and the left posterior thalamic radiation/optic radiation (z = 5), the superior longitudinal fasciculus bilaterally (z = 22), and the superior and posterior corona radiata bilaterally (z = 35). A, Anterior; R, right.