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Bar charts showing ACE level and activity in post-mortem CSF samples in relation to AD and disease progression. Error bars indicate 1 SEM. (A-B) ACE level was significantly lower in AD than control CSF (p=0.030) and correlated inversely with Braak stage (p=0.010, rs =-0.252). ACE levels were significantly lower in Braak stages V-VI than 0-II (p=0.04). (C-D) ACE activity was greater in AD than control CSF but the difference did not reach significance (p=0.060).
