Table 1.
Characteristics of participants by measured creatinine clearance groups
| Measured creatinine clearance (ml/min/1.73 m2) |
|||||
|---|---|---|---|---|---|
| ≥90 | 60–89 | 45–59 | <45 | P-value | |
| Number (%) | 327 (36) | 363 (40) | 133 (15) | 94 (10) | |
| Demographics | |||||
| Age (years)±SD | 62±10 | 68±10 | 72±10 | 72±12 | <0.0001 |
| Sex (% Male) | 272 (83) | 290 (80) | 115 (86) | 77 (82) | 0.34 |
| Race | 0.56 | ||||
| Caucasian (%) | 185 (57) | 228 (62) | 91(68) | 55 (59) | |
| African-American (%) | 54 (17) | 53 (15) | 14 (11) | 20 (21) | |
| Other (%) | 87 (27) | 82 (23) | 28 (21) | 19 (20) | |
| Regular alcohol use (%) | 110 (34) | 93 (26) | 44 (33) | 14 (15) | 0.002 |
| Regular tobacco use (%) | 69 (21) | 66 (18) | 27 (20) | 17 (18) | 0.76 |
| Physically active (%) | 225 (69) | 233 (65) | 88 (66) | 43 (46) | 0.001 |
| Medical history | |||||
| Hypertension (%) | 229 (70) | 244 (67) | 99 (74) | 77 (82) | 0.02 |
| Diabetes mellitus (%) | 82 (25) | 86 (24) | 34 (26) | 34 (36) | 0.11 |
| Myocardial infarction (%) | 172 (53) | 181 (50) | 80 (60) | 59 (63) | 0.06 |
| Angioplasty (%) | 131 (40) | 129 (36) | 58 (44) | 43 (46) | 0.20 |
| Coronary bypass (%) | 107 (33) | 136 (38) | 49 (37) | 42 (45) | 0.20 |
| Heart failure (%) | 42 (13) | 63 (17) | 27 (20) | 26 (28) | 0.007 |
| Angina (%) | 71 (22) | 56 (15) | 20 (15) | 14 (15) | 0.11 |
| Measurements | |||||
| Body mass index (kg/m2)±SD | 29.2±5.5 | 28.4±5.1 | 27.4±4.7 | 27.6±6.3 | 0.003 |
| Haemoglobin (g/l)±SD | 143±12 | 139±14 | 135±14 | 131±16 | <0.0001 |
| Albumin (g/l)±SD | 40±3 | 39±3 | 39±3 | 38±4 | <0.0001 |
| C-reactive protein (mg/dl)* | 1.9 [0.8, 4.1] | 2.2 [0.8, 4.8] | 2.4 [1.0, 4.2] | 3.2 [1.4, 7.2] | 0.003 |
| Total cholesterol (mmol/l)±SD | 4.6±1.1 | 4.6±1.0 | 4.5±1.2 | 4.6±1.1 | 0.68 |
| LDL cholesterol (mol/L)±SD | 2.7±0.9 | 2.6±0.8 | 2.6±1.0 | 2.7±0.9 | 0.34 |
| HDL cholesterol (mmol/l)±SD | 1.2±0.3 | 1.2±0.4 | 1.2±0.4 | 1.2±0.4 | 0.76 |
| Triglycerides (mmol/l)* | 1.3 [0.8, 1.8] | 1.3 [0.8, 1.9] | 1.1 [0.8, 1.7] | 1.3 [0.9, 2.0] | 0.32 |
| Medication use | |||||
| β blockers (%) | 169 (52) | 216 (60) | 83 (62) | 59 (63) | 0.06 |
| Aspirin (%) | 256 (78) | 296 (82) | 95 (71) | 66 (70) | 0.03 |
| Statins (%) | 210 (64) | 233 (64) | 87 (65) | 61 (65) | 0.99 |
| ACE/ARB (%) | 155 (47) | 184 (51) | 70 (53) | 61 (65) | 0.03 |
*
Median [Intra-quartile range].