Table 1.
Detection of known and validated submicroscopic copy-number variations onto high-density BAC, SNP and oligonucleotide microarrays
Patient | Copy number | Chromosome | Size (Mb) | No. of targets in region | Average ratio targets in region | Detected by HMMa | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
32k | 100k | 250k | 385k | 32k | 100k | 250k | 385k | 100k | 250k | 385k | ||||
BACs | SNPs | SNPs | Oligos | BACs | SNPs | SNPs | Oligos | SNPs | SNPs | Oligos | ||||
1 | Loss | 1 | 3.93 | 42 | 125 | 230 | n.d. | −0.41 | −0.51 | −0.45 | n.d. | Yes | Yes | n.d. |
2 | Gain | 1 | 2.12 | 21 | 50 | 120 | 176 | 0.44 | 0.49 | 0.77 | 0.59 | Yes | Yes | Yes |
3 | Loss | 2 | 0.92 | 11 | 47 | 64 | 127 | −0.59 | −0.43 | −0.52 | −0.45 | Yes | Yes | Yes |
4 | Gain | 5 | 1.24 | 16 | 40 | n.d. | n.d. | 0.29 | 0.30 | n.d. | n.d. | Yes | n.d. | n.d. |
5 | Loss | 7 | 0.35 | 18 | 1 | 13 | 30 | −0.23 | −0.52 | −0.40 | −0.24 | No | No | Yes |
6 | Gain | 9 | 0.23 | 5 | 23 | 38 | 40 | 0.35 | 0.30 | 0.47 | 0.27 | Yes | Yes | Yes |
7 | Loss | 9 | 2.85 | 30 | 145 | 320 | n.d. | −0.39 | −0.45 | −0.44 | n.d. | Yes | Yes | n.d. |
8 | Loss | 9 | 0.54 | 6 | 22 | 70 | 88 | −0.50 | −0.44 | −0.44 | −0.37 | Yes | Yes | Yes |
9 | Loss | 11 | 9.15 | 80 | 551 | 923 | 1299 | −0.35 | −0.47 | −0.47 | −0.50 | Yes | Yes | Yes |
10 | Gain | 12 | 2.30 | 39 | 69 | n.d. | 353 | 0.32 | 0.26 | n.d. | 0.23 | Yes | n.d. | Yes |
11 | Loss | 15 | 1.65 | 16 | 4 | 40 | 204 | −0.33 | −0.36 | −0.50 | −0.35 | No | Yes | Yes |
12 | Gain | 17 | 2.89 | 28 | 64 | 151 | 420 | 0.37 | 0.26 | 0.46 | 0.29 | Yes | Yes | Yes |
12 | Gain | 17 | 1.43 | 14 | 18 | 91 | 198 | 0.36 | 0.19 | 0.44 | 0.31 | Yes | Yes | Yes |
12 | Gain | 17 | 2.88 | 30 | 205 | 279 | 442 | 0.41 | 0.29 | 0.45 | 0.28 | Yes | Yes | Yes |
12 | Gain | 17 | 1.48 | 24 | 21 | 64 | 189 | 0.33 | 0.26 | 0.52 | 0.31 | Yes | Yes | Yes |
13 | Loss | 22 | 2.66 | 35 | 36 | 130 | 306 | −0.41 | −0.47 | −0.41 | −0.23 | Yes | Yes | Yes |
aAll copy-number variations were initially detected by an automated HMM on the 32k BAC array.