Figure 1.
Characterization of natural AAV serotypes. rAAV CMV-GFP vector transduction efficiencies (gray bars) on primary human astrocytes (gMOI = 103–105) using seven AAV serotypes (1, 4–6, 8, and 9) varied significantly (n = 3, error bars represent SD). Binding levels (white bars) of each serotype to primary human astrocytes matched the relative transduction efficiencies, except for surprisingly high binding levels of AAV4, which transduced primary human astrocytes poorly (n = 3, error bars represent SD). AAV, adeno-associated virus; CMV, cytomegalovirus; GFP, green fluorescent protein; gMOI, genomic multiplicity of infection.