Figure 5.
Wild-Type Telomerase Elongates Telomeres Incrementally across Generations; Example of mTR+/− HG4 Family Is Shown
(A) Breeding scheme of wt∗ mice with nomenclature.
(B–D) Frequency distribution of telomere length as examined by qFISH on metaphase splenocytes for each wt∗ generation, compared with true wild-types, are shown in each panel (n = 2 mice per group). Degenerative phenotypes resolve with successive telomere elongation, as shown by an increase in testes weight (C) and the decreasing frequency of aberrant tubules in (D). The number of examined mice is shown below each column, and testes weight was corrected for body weight. Mice were examined at 12 mo of age.