Skip to main content
. 2010 Jan 15;6(1):e1000812. doi: 10.1371/journal.pgen.1000812

Table 1. Gene Set Analysis demonstrates a signature of DNA damage in FRDA patients.

Set Name Score p-Value FDR
BLEO_HUMAN_LYMPH_HIGH_4HRS_UP −0.37 0.044 0.6916
GENOTOXINS_ALL_24HRS_REG −0.4663 0.044 0.6916
MMS_HUMAN_LYMPH_LOW_4HRS_DN −1.1264 0.01 0.5726
MMS_MOUSE_LYMPH_HIGH_4HRS_UP −0.7369 0.002 0.4453
P53GENES_ALL 0.3779 0.04 0.9698
UVB_NHEK1_C6 −0.4047 0.022 0.6203
UVB_NHEK1_DN −0.4473 0.014 0.5726
UVB_NHEK2_DN −0.3615 0.012 0.5726
UVB_NHEK3_C2 −0.7741 0.004 0.5726
UVC_HIGH_ALL_DN −0.4171 0.006 0.5726
UVC_HIGH_D1_DN −0.4286 0.032 0.668
UVC_HIGH_D2_DN −0.366 0.064 0.7433
UVC_HIGH_D7_DN −0.4576 0.018 0.5726
UVC_HIGH_D9_DN −0.733 0.008 0.5726
UVC_TTD_4HR_DN −0.5704 0.006 0.5726
UVC_TTD_8HR_DN −0.3107 0.044 0.6916
UVC_TTD_ALL_DN −0.4737 0.008 0.5726
UVC_TTD-XPCS_COMMON_DN −0.4533 0.012 0.5726
UVC_XPCS_4HR_DN −0.5225 0.014 0.5726
UVC_XPCS_4HR_UP −0.6511 0.028 0.645
UVC_XPCS_8HR_DN −0.5428 0.008 0.5726
UVC_XPCS_ALL_DN −0.5414 0.006 0.5726
UV-CMV_UNIQUE_HCMV_6HRS_DN −0.2488 0.02 0.5938

GSA was performed using the Molecular Signatures Database. Significantly enriched gene sets included 23 sets associated to genotoxic stress response.