Table 2.
Study subject N and characteristics (Table is updated from Shenton et al. (1997); McCarley et al. (1999b) Abbreviations: Tot Subjs = Total Subjects; NL Ctrls and NCL = Normal Controls; SZ = Schizophrenics; BP = Bipolar; SZAFF = Schizoaffective Disorder; FE = First Episode; TLE = Temporal Lobe Epilepsy; OBS = Organic Brain Syndrome; AD = Alzheimer’s disease; DEL Dis = Delusional Disorder, SZPHM = Schizophreniform Disorder, Maj Dep = Major Depression; SPD = Schizotypal Personality Disorder;10 = First Degree; Tx = Treatment; td = Tardive Dyskinesia; Audhall = Auditory Hallucinations; STATEHOSPSZ = State Hospitalized SZ; VAHOSPSZ = Veterans Affair Hospitalized SZ; CSP = Cavum Septi Pellucidi; NN = Neuroleptic Naive; TN = Typical Neuroleptic; AN = Atypical Neuroleptic; PBC = Pregnancy and Birth Complications)
Authors | Tot Subjs | NL Ctrls | SZs | Bipolars | SZAFFs | Other | Comments |
---|---|---|---|---|---|---|---|
Altshuler et al., 1998 | 44 | 18 | 14 | 12 | |||
Andreasen et al., 1990 | 101 | 47 | 54 | ||||
Andreasen et al., 1994a | 142 | 90 | 52 | ||||
Andreasen et al, 1994b | 86 | 47 | 39 | ||||
Arciniegas et al., 1999 | 48 | 27 | 21 | Paranoid SZ | |||
Baaré et al., 1999 | 27 | 14 | 13 | ||||
Barr et al., 1997 | 113 | 42 | 26 | 6 | 39 | FE SZ, FE SZAFF, Other = TLE | |
Barta et al., 1990 | 30 | 15 | 15 | ||||
Barta et al., 1997a | 60 | 32 | 28 | ||||
Barta et al., 1997b | 41 | 18 | 11 | 12 | SZ = Late onset, Other = AD | ||
Becker et al., 1990 | 20 | 10 | 10 | ||||
Becker et al., 1996 | 40 | 20 | 20 | ||||
Bilder et al., 1994asym | 121 | 51 | 58 | 12 | FE SZ, FE SZAFF | ||
Bilder et al., 1999asym | 235 | 67 | 87 | 81 | SZ FE/SZPHM, SZAFF or SZAFF/Mood Disorder | ||
Blackwood et al., 1991 | 64 | 33 | 31 | ||||
Bogerts et al., 1990 | 59 | 25 | 34 | FE SZ | |||
Bogerts, 1993b | 37 | 18 | 19 | ||||
Bornstein et al., 1992 | 103 | 31 | 72 | ||||
Breier et al., 1992 | 73 | 29 | 44 | ||||
Bryant et al., 1999 | 96 | 37 | 59 | ||||
Buchanan et al., 1993 | 71 | 30 | 41 | 17SZ = Deficit Symptoms, 24 SZ = no Deficit Symptoms | |||
Buchanan et al., 1998 | 42 | 24 | 18 | ||||
Buchsbaum et al., 1996 | 35 | 15 | 20 | ||||
Buchsbaum et al., 1997 | 46 | 23 | 11 | 12 | SZ or SZAFF, Other = SPD | ||
Cannon et al., 1998 | 191 | 56 | 63 | 12 | 60 | Familial SZ, Other = 1 0 non-psychotic relatives | |
Casanova et al., 1990 | 32 | 16 | 16 | NL MZ twin/SZ MZ Twin | |||
Chakos et al., 1994 | 39 | 10 | 21 | 8 | FE SZ | ||
Chakos et al., 1995 | 15 | 15 | 8SZ neuroleptics/changed to atypical, 7SZ | ||||
Chua et al., 2000 | 115 | 35 | 27 | 53 | Familial SZ, Other = 1 0 non-psychotic relatives | ||
Coffman et al., 1989 | 143 | 34 | 58 | 51 | Other = Bipolar Disorder and SZAFF Disorder | ||
Colombo et al., 1993 | 36 | 18 | 18 | ||||
Colombo et al., 1994 | 34 | 15 | 19 | ||||
Copolov et al., 2000 | 218 | 140 | 46,16 | 10 | 4 | 2 | 46FE SZ,10FE BP,4FE SZAFF, 2FE = other psychosis |
Corey-Bloom et al., 1995 | 58 | 28 | 30 | ||||
Corson et al., 1999a | 79 | 43 | 36 | FE SZ | |||
Dauphinais et al., 1990 | 49 | 21 | 28 | SZ or SZAFF | |||
Degreef et al., 1990 | 42 | 17 | 25 | FE SZ | |||
Degreef et al., 1992a | 65 | 25 | 40 | FE SZ | |||
Degreef et al., 1992b | 108 | 46 | 62 | FE SZ | |||
Degreef et al., 1992c | 194 | 46 | 19,62 | 67 | 19SZ, 62FE SZ, Other = post-mortem study, 39 NCL, 28SZ | ||
Deicken et al., 1999 | 41 | 18 | 23 | ||||
DeLisi et al., 1988 | 42 | 18 | 24 | ||||
DeLisi et al., 1991 | 65 | 20 | 15,30 | 15SZ, 30FE SZ | |||
DeLisi et al., 1992 | 111 | 33 | 50,28 | 50FE SZAFF/SZ, 28SZAFF/SZ 2yr FUP | |||
DeLisi et al., 1993 | 132 | 47 | 50,19 | 13 | 3 | 50FE SZPHM, 19FE SZ, 13FE SZAFF,3FE other | |
DeLisi et al., 1994 | 125 | 40 | 85 | All FE SZ, SZPHM, or SZAFF | |||
DeLisi et al., 1997 | 70 | 20 | 50 | All FE SZ, SZPHM, or SZAFF | |||
DeQuardo et al., 1996 | 28 | 14 | 14 | ||||
DeQuardo et al., 1999 | 42 | 22 | 20 | FE SZ | |||
Di Michele et al., 1992 | 42 | 17 | 25 | ||||
Downhill et al., 2000 | 70 | 30 | 27 | 13 | Other = SPD | ||
Egan et al., 1994 | 32 | 16 | 16 | ||||
Elkashef et al., 1994 | 51 | 26 | 25 | ||||
Flaum et al., 1995 | 189 | 87 | 102 | ||||
Frangou et al., 1997 | 126 | 39 | 32 | 55 | Familial SZ, Other = 1 0 non-psychotic relatives | ||
Frederikse et al., 2000 | 60 | 30 | 30 | ||||
Fukuzako et al., 1996a | 36 | 18 | 18 | ||||
Fukuzako et al., 1996b | 113 | 41 | 72 | ||||
Fukuzako et al., 1997 | 56 | 28 | 28 | ||||
Goldstein et al., 1999 | 55 | 26 | 29 | ||||
Guenther et al., 1989 | 62 | 31 | 31 | ||||
Gunther et al., 1991 | 62 | 31 | 31 | ||||
Gur et al., 1994 | 162 | 81 | 81 | ||||
Gur et al., 1998a | 224 | 128 | 96 | 21NN, 48TN, 27F/up and AN | |||
Gur et al., 1998b | 57 | 17 | 20,20 | 20SZ, 20 FE SZ | |||
Gur et al., 1999 | 260 | 130 | 130 | 51NN, 79 previously Tx | |||
Gur et al., 2000a | 210 | 110 | 100 | 39NN, 61 previously Tx | |||
Gur et al., 2000b | 151 | 81 | 70 | 29NN, 41 previously Tx | |||
Hajek, 1997 | 20 | 10 | 10 | ||||
Harvey et al., 1993 | 82 | 34 | 48 | ||||
Hauser et al., 1989 | 71 | 25 | 24 | 22 | |||
Havermans et al., 1999 | 47 | 17 | 30 | 15SZ with Audhall, 15SZ no Audhall | |||
Hazlett et al., 1999 | 72 | 32 | 27 | 13 | Other = SPD | ||
Hirayasu et al., 1998 | 51 | 18 | 17 | 14 | 2 | FE SZ, FE BP, other = depressed, psychotic | |
Hirayasu et al., 1999 | 61 | 20 | 17 | 21 | 3 | FE SZ, FE BP, other = depressed, psychotic | |
Hirayasu et al., 2000 | 66 | 22 | 20 | 24 | FE SZ, FE BP | ||
Hoff et al., 1992 | 113 | 57 | 56 | SZPHM | |||
Hoff et al., 1994 | 97 | 35 | 56 | FE SZ, SZPHM, SZAFF, all but 1 NN | |||
Hokama et al., 1995 | 30 | 15 | 15 | ||||
Holinger, et al., 1999 | 18 | 10 | 8 | ||||
Jernigan et al., 1991 | 66 | 24 | 42 | ||||
Johnstone et al., 1989 | 62 | 21 | 21 | 20 | |||
Jurjus et al., 1993 | 164 | 37 | 67 | 60 | BP and SZAFF | ||
Kawasaki et al., 1993 | 30 | 10 | 20 | ||||
Kelsoe et al., 1988 | 38 | 14 | 24 | ||||
Keshavan et al., 1995 | 11 | 11 | 6FE SZ, 5 Other Psychoses | ||||
Keshavan et al., 1998a | 42 | 17 | 16 | 9 | FE SZ, Other = non-SZ Psychotic | ||
Keshavan et al., 1998b | 42 | 17 | 17 | 8 | FE SZ, Other = non-SZ Psychotic | ||
Kikinis et al., 1994 | 30 | 15 | 15 | ||||
Kleinschmidt et al., 1994 | 52 | 26 | 26 | FE SZ | |||
Kulynych et al., 1995 | 24 | 12 | 12 | ||||
Kulynych et al., 1996 | 24 | 12 | 12 | ||||
Kwon et al., 1998 | 113 | 46 | 15,15 | 14 | 21,2 | 15SZ,15FE SZ,21SPD,2FE Dp Psychotic Depressed Psychotic | |
Kwon et al., 1999 | 32 | 16 | 16 | ||||
Lauriello et al., 1997 | 74 | 37 | 37 | ||||
Lawrie et al., 1999 | 150 | 30 | 20 | 100 | FE SZ, Other = high risk for SZ | ||
Levitt et al., 1999 | 30 | 15 | 15 | ||||
Lewine et al., 1990 | 59 | 31 | 28 | Other = 12 MAJ DEP/SZAFF, 14 Unspec, 2 OBS | |||
Lim et al., 1996 | 73 | 51 | 22 | FE SZ | |||
Marsh et al., 1994 | 74 | 41 | 33 | ||||
Marsh et al., 1997 | 108 | 52 | 56 | ||||
Marsh et al., 1999 | 152 | 52 | 100 | 55STATEHOSPSZ, 44VAHOSPSZ | |||
Mathew et al., 1985a | 24 | 12 | 12 | ||||
Mathew et al., 1985b | 36 | 18 | 18 | ||||
McNeil et al., 2000 | 44 | 22 | 22 | NL MZ twin/SZ MZ Twin | |||
Meisenzahl et al., 1999 | 46 | 23 | 23 | ||||
Meisenzahl et al., 2000 | 60 | 30 | 30 | ||||
Menon, et al., 1995 | 40 | 20 | 20 | ||||
Mion et al., 1991 | 48 | 16 | 32 | 16SZ with td, 16SZ without td | |||
Narr et al., 2000 | 53 | 28 | 25 | ||||
Nasrallah et al., 1986 | 79 | 41 | 38 | ||||
Nasrallah et al., 1990 | 91 | 35 | 56 | ||||
Niemann et al., 2000 | 40 | 20 | 20 | FE SZ | |||
Niznikiewicz et al., 2000 | 30 | 15 | 15 | ||||
Noga et al., 1995 | 28 | 14 | 14 | ||||
Nopoulos et al., 1995 | 48 | 24 | 22 | 2 | FE SZ, FE SZAFF | ||
Nopoulos et al., 1996 | 101 | 47 | 54 | 44SZ with no large CSP, 10 SZ with large CSP | |||
Nopoulos et al., 1997 | 130 | 75 | 52 | 3 | |||
Nopoulos et al., 1999 | 130 | 65 | 65 | ||||
Ohnuma et al., 1997 | 20 | 10 | 10 | FE SZ | |||
Pearlson et al., 1997b | 133 | 60 | 46 | 27 | |||
Petty et al., 1995 | 28 | 14 | 14 | ||||
Portas et al., 1998 | 30 | 15 | 15 | ||||
Raine et al., 1990 | 46 | 18 | 15 | 13 | Other = psychiatric controls | ||
Raine et al., 1992 | 54 | 19 | 17 | 18 | Other = psychiatric controls | ||
Rajarethinam et al., 2000 | 40 | 20 | 20 | ||||
Razi et al., 1999 | 71 | 31 | 27,13 | 27SZ, 13FE SZ/SZAFF/SZPHN | |||
Reite et al., 1997 | 40 | 20 | 20 | Paranoid SZ | |||
Rossi et al., 1988 | 24 | 12 | 12 | ||||
Rossi et al., 1989a | 26 | 11 | 15 | ||||
Rossi et al., 1989b | 24 | 12 | 12 | ||||
Rossi et al., 1990 | 30 | 13 | 17 | ||||
Rossi et al., 1991 | 26 | 10 | 16 | ||||
Rossi et al., 1992 | 32 | 12 | 20 | ||||
Rossi et al., 1993 | 39 | 16 | 23 | ||||
Rossi et al., 1994a | 33 | 14 | 19 | ||||
Rossi et al., 1994b | 45 | 23 | 22 | ||||
Roy et al., 1998 | 51 | 15 | 22 | 14 | |||
Sachdev and Brodaty,1999 | 79 | 30 | 49 | 25 Late onset SZ, 24 Early onset SZ | |||
Sanfilipo et al., 2000a | 102 | 29 | 73 | ||||
Sanfilipo et al., 2000b | 82 | 29 | 53 | ||||
Schlaepfer et al., 1994 | 133 | 60 | 46 | 27 | |||
Schwartz et al., 1992 | 99 | 51 | 48 | ||||
Schwarzkopf et al., 1990 | 40 | 20 | 20 | ||||
Scott et al., 1993 | 140 | 79 | 52 | 9 | Controls = non-SZ Inpatients | ||
Shenton et al., 1991 | 22 | 10 | 12 | ||||
Shenton et al., 1992 | 30 | 15 | 15 | ||||
Shihabuddin et al., 1998 | 42 | 24 | 16 | 2 | 7NN, 11 Drug Free SZ/SZAFF | ||
Shioiri et al., 1996 | 245 | 92 | 40 | 69 | 44 | Other = Unipolar Depression | |
Snyder et al., 1998 | 134 | 52 | 82 | FE SZ | |||
Staal et al., 1998 | 64 | 32 | 16 | 16 | Other = Same Sex Sib of SZ | ||
Staal et al., 2000 | 64 | 32 | 16 | 16 | Other = Same Sex Sib of SZ | ||
Stefanis et al., 1999 | 74 | 26 | 48 | 27SZ with no PBCs, 21SZ with PBCs | |||
Stratta et al., 1989 | 40 | 20 | 20 | ||||
Suddath et al., 1989 | 34 | 17 | 17 | ||||
Suddath et al., 1990 | 30 | 15 | 15 | NL MZ twin/SZ MZ Twin | |||
Sullivan et al., 1998 | 198 | 65 | 71 | 62 | Other = Detoxified Chronic Etoh | ||
Swayze et al., 1992 | 149 | 47 | 54 | 48 | |||
Symonds et al., 1999 | 287 | 63 | 62 | 162 | 58 AD, 52 Etoh, 52 +HIV | ||
Szeszko et al., 1999 | 45 | 26 | 19 | FE SZ | |||
Tibbo et al., 1998 | 144 | 65 | 79 | ||||
Tune et al., 1996 | 29 | 15 | 14 | ||||
Turetsky et al., 1995 | 224 | 128 | 96 | 75 SZ previously Tx, 21 SZ NN | |||
Turetsky et al., 2000 | 48 | 22 | 26 | ||||
Uematsu and Kaiya, 1988 | 57 | 17 | 40 | ||||
Uematsu and Kaiya, 1989 | 57 | 17 | 40 | ||||
Velakoulis et al., 1999 | 218 | 140 | 46,32 | 46SZ, 32FE SZ | |||
Vita et al., 1995 | 34 | 15 | 19 | ||||
Whitworth et al., 1998 | 103 | 32 | 30,41 | 30SZ, 41FE SZ | |||
Wible et al., 1995 | 29 | 15 | 14 | ||||
Wible et al., 1997 | 30 | 15 | 15 | ||||
Woodruff et al., 1993 | 74 | 44 | 30 | ||||
Woodruff et al., 1997a | 85 | 43 | 42 | ||||
Woodruff et al., 1997b | 85 | 43 | 42 | ||||
Woods et al., 1996 | 38 | 19 | 17 | 2 | |||
Zipursky et al., 1992 | 42 | 20 | 22 | ||||
Zipursky et al., 1994 | 42 | 20 | 22 | ||||
Zipursky et al., 1997 | 54 | 17 | 23 | 14 | |||
Zipursky et al., 1998a | 138 | 61 | 77 | FE SZ, FE SZPHM, FE SZAFF, FE DEL DIS, Psychosis NOS | |||
Zipursky et al., 1998b | 108 | 82 | 26 | FE of non-affective Psychosis |