Table 4.
Multivariate Logistic Regression Analyses of Nocebo Effect
| Side Effect | Variables of Nocebo Effect | OR | P Value |
|---|---|---|---|
| Restlessness | Baseline FACIT-F Total Score | 1.00 | 0.94 |
| Baseline FACT-G Physical Well-being score | 0.99 | 0.87 | |
| Baseline Performance Status | 1.39 | 0.20 | |
| Baseline ESAS Anxiety | 1.24 | 0.02 | |
| Baseline ESAS Pain | 1.07 | 0.41 | |
| Baseline ESAS Drowsiness | 1.05 | 0.53 | |
| Baseline ESAS Shortness of breath | 1.00 | 0.96 | |
| Baseline ESAS Well-being | 1.05 | 0.65 | |
| Behavioral change | Age | 1.10 | 1.01 |
| Baseline ESAS Fatigue | 0.67 | 0.05 | |
| Baseline ESAS Nausea | 0.84 | 0.41 | |
| Primary cancer diagnosis | 3.29 | 0.08 | |
| Mini-Mental Exam Score | 0.87 | 0.63 | |
| Baseline FACT-G Social/Family well-being | 0.84 | 0.11 | |
| Dizziness | Baseline FACIT-F Total Score | 1.01 | 0.46 |
| Baseline FACT-G Physical Well-being | 0.99 | 0.95 | |
| Baseline Performance status | 1.87 | 0.03 | |
| Baseline Drowsiness | 1.04 | 0.62 | |
| Baseline ESAS Sleep | 1.06 | 0.50 | |
| Baseline ESAS Well-being | 1.20 | 0.06 | |
| Tachycardia | Marital Status | 0.58 | 0.46 |
| Educational Level | 4.83 | 0.06 | |
| Baseline FACT-G Fatigue subscale | 1.23 | 0.001 | |
| Baseline Performance Status | 3.97 | 0.03 | |
| Baseline ESAS Depression | 1.54 | 0.02 | |
| Baseline ESAS Sleep | 1.40 | 0.04 | |
| Baseline ESAS Drowsiness | 0.85 | 0.46 | |
| Baseline ESAS Nausea | 1.04 | 0.83 | |
| Baseline ESAS Well-being | 1.04 | 0.84 | |
| Insomnia | Baseline Mini Mental Score | 1.80 | 0.01 |
| Baseline FACIT-F Total Score | 1.01 | 0.77 | |
| Baseline FACT-G Functional Well-being | 0.85 | 0.01 | |
| Baseline FACT-G Physical well-being | 0.90 | 0.17 | |
| Baseline FACT-G Emotional well-being | 0.86 | 0.27 | |
| Baseline Performance Status | 1.32 | 0.49 | |
| Baseline ESAS Nausea | 0.76 | 0.04 | |
| Baseline ESAS Sleep | 1.26 | 0.04 | |
| Baseline ESAS Anxiety | 1.11 | 0.51 | |
| Baseline ESAS Drowsiness | 1.02 | 0.87 | |
| Baseline ESAS Pain | 1.02 | 0.91 | |
| Anorexia | Gender | 0.55 | 0.21 |
| Marital Status | 0.85 | 0.71 | |
| Baseline ESAS Appetite | 1.23 | 0.01 | |
| Baseline FACIT-F Total Score | 1.00 | 0.91 | |
| Baseline FACT-G Fatigue subscale | 0.92 | 0.01 | |
| Baseline FACT-G Functional Well-being | 1.01 | 0.91 | |
| Baseline FACT-G Physical Well-being | 0.98 | 0.72 | |
| Baseline ESAS Fatigue | 0.90 | 0.53 | |
| Baseline ESAS Drowsiness | 1.04 | 0.66 | |
| Baseline Shortness of breath | 1.08 | 0.33 | |
| Baseline ESAS Sleep | 1.14 | 0.12 | |
| Baseline ESAS Well-being | 1.07 | 0.51 | |
| Nausea | Age | 0.97 | 0.33 |
| Educational Level | 2.73 | 0.05 | |
| Mini Mental Score | 1.72 | 0.19 | |
| Baseline FACIT-F Total Score | 1.00 | 0.80 | |
| Baseline FACT-G Physical Well-being | 1.11 | 0.50 | |
| Baseline ESAS Nausea | 2.10 | 0.004 | |
| Baseline ESAS Anxiety | 0.97 | 0.85 | |
| Baseline ESAS Shortness of breath | 1.02 | 0.84 | |
*
Reporting of other side effects such as slurred speech, vertigo, and skin problems were not significantly associated with any of the variables tested for nocebo effect.