Table 2.
Cardiovascular risk markers and hepatic aminotransferases (Mean ± SEM) in GH-Deficient and GH-Sufficient Obese premenopausal women.
| GH Peak (≤3 ng/mL) | GH Peak (>3 ng/mL) | P value | |
|---|---|---|---|
| n = 9 | N = 39 | ||
| Age (year) | 42.3 ± 2.3 | 30.4 ± 2.4 | NS |
| BMI (kg/m2) | 45.5 ± 1.6 | 33.8 ± 1.0 | .007 |
| Mid-waist circumference (cm) | 117 ± 2.3 | 99.0 ± 3.1 | .039 |
| Waist/hip ratio | 0.97 ± 0.04 | 0.89 ± 0.02 | NS |
| Total body fat (%) | 46.9 ± 1.0 | 36.8 ± 1.2 | .004 |
| Trunk fat (cm2) | 185.0 ± 6.7 | 131.2 ± 9.2 | .048 |
| IGF-I (ng/mL) | 103.3 ± 6.5 | 158.3 ± 18.2 | NS |
| IGFBP-3 | 4.9 ± 0.2 | 4.6 ± 0.3 | NS |
| Total cholesterol (mg/dL) | 231 ± 14.0 | 165 ± 8.3 | .039 |
| HDL (mg/dL) | 43.5 ± 2.0 | 54.2 ± 1.8 | NS |
| LDL (mg/dL) | 173 ± 2.5 | 95.2 ± 7 | .044 |
| Triglyceride (mg/dL) | 172 ± 29.5 | 86.4 ± 13.4 | .047 |
| Fasting glucose (mg/dL) | 99.7 ± 2.0 | 91.7 ± 2.0 | NS |
| Fasting Insulin (μU/mL) | 20.9 ± 0.3 | 10.8 ± 1.3 | .005 |
| HOMA-IR | 5.3 ± 0.25 | 2.6 ± 1.5 | .018 |
| Leptin | 20.1 ± 3.5 | 24.7 ± 3.6 | NS |
| GOT (IU/L) | 31.3 ± 2.0 | 17.6 ± 1.0 | .012 |
| GPT (IU/L) | 42.3 ± 4.4 | 20.2 ± 1.5 | .022 |
| GGT (IU/L) | 65.0 ± 9.2 | 13.8 ± 1.2 | .007 |