Table 1.
Gene ontology of gene changes in trisomy 21 hNPCs
Gene names | Number of genes | Biological process |
---|---|---|
ABL1, ACTN2, ACVR1, ADRA1A, AGT, AHR, APOE, ARF6, ATP7A, ATXN1, BCAR1, BCL2L11, BCL2L14, BECN1, BRCA2, BRE, BTG1, BTG2, C16orf5, CASP1, CASP6, CASP7, CDKN2A, CDKN2C, CFLAR, CLN8, CTNNA1, DBC1, DIP, DLG5, EAF2, EEF1A2, EGLN3, EIF5A, ELMO1, ERC1, FAS, GADD45A, GAL, GJA1, GSK3B, GSPT1, HDAC1, HIP1, IGFBP3, IL12A, IL24, ISG20L1, LITAF, MCL1, MLL, NLRP1, NOTCH2, PAX3, PDCD4, PDCD6, PEG3, PHLDA1, PLAGL1, PPP3CC, RYBP, SERPINB9, SFRP1, SIVA1, SOCS2, SOD2, STK17A, STK17B, STK4, TCF7L2, TGFB3, TIMP3, TNFAIP3, TNFRSF10A, TNFRSF11B, TRAF7, TRIM69, ZAK, ZBTB16 | 81 | cell death apoptosis |
ABL1, ACSL6, ACVR1, ACVR2A, ADRA1A, AGT, AHR, AIM2, ANG, APC, APOE, ARHGAP20, AURKB, BCAR1, BCAT1, BIN1, BLM, BLZF1, BMP2, BRCA2, BTG1, BTG2, CABLES1, CALCRL, CCNE1, CCNE2, CDC14B, CDC25A, CDCA7, CDK3, CDK6, CDK9, CDKN2A, CDKN2C, CENPE, CENPF, CHRNA7, CLIP1, CP110, CSRP2, CTBP1, CTNNA1, CTNNBIP1, DAB2IP, DBC1, DBF4, DIAPH2, DIRAS3, DLG5, DSCC1, EDN1, EGF, EIF5A, ERBB2, ERBB3, FGF9, FGFR1OP, FLT4, GADD45A, GAL, GAS7, GJA1, GLI3, GMNN, GNL3, GSPT1, HBP1, HDAC6, HELLS, HHEX, HLA-DQB1, HRASLS3, HUS1, IL12A, JAG2, KANK1, KLF4, KLHDC3, LYN, MAPK4, MCM2, MKI67, MPHOSPH9, MTSS1, MXD1, NEK1, NOTCH2, NOX4, NPY, NRP1, NUMBL, PARD6B, PDCD4, PDGFC, PDGFD, PDGFRA, PDS5A, PDS5B, PES1, PLAGL1, PMS1, PPP1CB, PRR5, PSMF1, PTCH1, RAD51, RBBP8, RIF1, S100A11, S100A6, SASS6, Septin 11, Septin 8, SFTPD, SMC2, SMC4, STAG2, STARD13, STIL, TBX2, TCF7L2, TERF2, TFDP2, TGFB3, TGFBI, TXN, TXNRD1, UHMK1, USP16, XRN1, ZAK | 131 | cell division cell cycle cell proliferation |
ACSL6, AFF2, ALK, APOE, ATP2B2, ATP7A, B3GNT2, BMP2, BPTF, BRCA2, BTG2, C17orf47, CDK5RAP2, CHL1, CLN8, CTNNA1, CYFIP1, DLX2, DLX5, EGF, EGR2, EMX2, EN2, EPHB3, ERBB2, FARP2, FEZ2, GJA1, GLI3, HHEX, JAG2, KLF4, MAPT, MCL1, NOTCH2, NR2F1, NRP1, NRXN3, NTNG1, NTNG2, NUMBL, OLIG2, PARD6B, ROBO1, RTN1, S100A6, SEMA4F, SLIT1, SLITRK1, SMAD2, SOX3, TCF7L2, ZIC1 | 54 | cell fate generation of neurons brain development |