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. 2010 Jan 28;133(2):349–361. doi: 10.1093/brain/awp309

Figure 6.

Figure 6

Intra-cerebral injection of IgGNMO + hC at Days 0, 3, and 5 causes loss of GFAP and AQP4 expression at Day 7. (A–D) Wild-type (WT) brain 7 days after injection of IgGNMO + hC. (A) GFAP and (B) AQP4 immunostain of lesion and perilesional area. (A) and (B) are sequential sections. Blue and green arrowheads mark corresponding vessels. Black arrowheads indicate fragmented GFAP+ processes within the lesion. Inset: reactive astrocyte. (C) GFAP and (D) AQP4 immunostain of contralateral (non-injected) hemisphere. Arrowheads indicate microvessels. (E) AQP4-null mouse (KO) brain injected with IgGNMO + hC immunostained for (left) GFAP and (right) AQP4. (F) WT mouse brain injected with IgGCON + hC immunostained for (left) GFAP and (right) AQP4. Bar 100 µm (A and B), 50 µm (C–F), 20 µm (A, Inset).