Table 2.
Prefrontal Cortex Morphometry and Composition by Alcohol Use Group and Gender
| Female controls (n = 7) mean (SD) [range] | AUD females (n = 5) mean (SD) [range] | Male controls (n = 10) mean (SD) [range] | AUD males (n = 9) mean (SD) [range] | |
|---|---|---|---|---|
| Intracranial volume (ICV) (cc3)a | 1,519.1 (117.1) [1,374.0–1,703.1] | 1,549.0 (86.0) [1,430.0–1,636.6] | 1,674.2 (158.0) [1,438.4–2,015.9] | 1,658.9 (80.2) [1,551.7–1,842.1] |
| Posterior PFC/ICV (cc3) | 0.1040 (0.0071) [0.0908–0.1135] | 0.1007 (0.0084) [0.0939–0.1149] | 0.1026 (0.0112) [0.0843–0.1178] | 0.1039 (0.0134) [0.0809–0.1248] |
| Anterior dorsal PFC/ICV (cc3) | 0.0663 (0.0058) [0.0577–0.0749] | 0.0643 (0.0064) [0.0568–0.0725] | 0.0656 (0.0095) [0.0482–0.0784] | 0.0709 (0.0093) [0.0585–0.0894] |
| Anterior ventral PFC/ICV (cc3)b | 0.0554 (0.0064) [0.0477–0.0678] | 0.0473 (0.0040) [0.0446–0.0541] | 0.0531 (0.0071) [0.0378–0.0642] | 0.0586 (0.0063) [0.0515–0.0684] |
| Posterior PFC WM/ICV (cc3) | 0.0364 (0.0031) [0.0321–0.0405] | 0.0354 (0.0032) [0.0327–0.0408] | 0.0372 (0.0049) [0.0302–0.0437] | 0.0373 (0.0053) [0.0282–0.0463] |
| Anterior dorsal PFC WM/ICV (cc3) | 0.0164 (0.0023) [0.0140–0.0197] | 0.0152 (0.0029) [0.0116–0.0185] | 0.0165 (0.0031) [0.0117–0.0210] | 0.0182 (0.0033) [0.0124–0.0231] |
| Anterior ventral PFC WM/ICV (cc3)c | 0.0140 (0.0024) [0.0113–0.0172] | 0.0113 (0.0010) [0.0100–0.0125] | 0.0139 (0.0020) [0.0093–0.0163] | 0.0149 (0.0019) [0.0123–0.0170] |
a
Notes: Females significantly smaller than males (p < 0.05);
b
Female AUD different than controls (p < 0.05);
c
Male AUD different than female AUD (p < 0.05). AUD, alcohol use disorders; WM, white matter volume; PFC = prefrontal cortex volume.