TABLE 1.
Clinical characteristics of the study population
| N | Male, No (%) | AAE, mean (SD), y | AAE, range, y | AAO, mean (SD), y | AAO, range, y | |
|---|---|---|---|---|---|---|
| PD Tier 1a | 36 | 16 (44.4) | 63.5 (10.2) | 42–79 | 56.0 (13.6) | 17–75 |
| PD Tier 2b | 595 | 250 (42.0) | 67.3 (8.4) | 22–91 | 61.2 (9.2) | 18–89 |
| Control Group 1c | 320 | 116 (36.3) | 69.4 (11.2) | 37–94 | NA | NA |
| Control Group 2d | 1321 | 624 (47.2) | 70.6 (5.3) | 64–101 | NA | NA |
AAE, age at enrollment; AAO, age at onset; NA, not applicable; PD, Parkinson’s disease.
a
Reported at least 1 first degree relative with PD.
b
Closest affected relative was either second degree (n = 3) or reported no family history of PD (n = 592).
c
Control subjects enrolled in Japan.
d
Control subjects of Japanese ancestry enrolled in King County, Washington.