. 2010 Mar 3;5(3):e9508. doi: 10.1371/journal.pone.0009508

Table 1. Descriptive statistics of metabolites in purine pathway.

Groups	Mean	Median	Firstqrt	Thirdqrt	p (HC vs FENNS)^*	p (BL vs 4w)^†
1. HC
UA	50606^‡	41927	30460	66970
Xan	183	87	52	171
Xant	40	11	7.53	22
G	6.57	6.51	3.07	8.66
Gr	9.65	7.40	2.82	11
Hx	1079	354	139	734
2. FENNS-BL
UA	37007	25663	20074	46560	0.0193
Xan	177	70	63	136	0.8210
Xant	80	34	19	53	0.0023 ^§
G	3.79	1.98	1.12	6.02	0.0156
Gr	13	7.58	2.82	18	0.5771
Hx	1190	412	200	865	0.8867
3. FENNS-4w
UA	36322	25163	21556	47095	0.0124	0.7510
Xan	103	65	57	98	0.1977	0.1014
Xant	43	25	21	48	0.0081	0.5965
G	2.31	1.30	0.84	2.83	0.0002	0.0003
Gr	7.79	2.82	2.82	8.71	0.2502	0.0405
Hx	662	347	170	817	0.6935	0.4261

* Wilcoxon rank sum test.

† Wilcoxon signed ranks test.

^‡

Each value represents ng/mL. Xant and Gr have some left-censored values, so the listed mean estimates may be too large by up to 3.76 (HC), 0.60 (FENNS-BL), 1.20 (FENNS-4W) for Xant, and 0.94 (HC), 0.79 (FENNS-BL), 1.47 (FENNS-4W) for Gr.

§ Significance with p<0.0083 in boldface, trends with p<0.0167, after Bonferroni correction.

Abbreviations: HC, healthy control subjects; FENNS, first-episode neuroleptic-naïve patients with schizophrenia; BL, baseline; 4w, 4-week treatment with antipsychotic drugs; UA, uric acid; Xan, xanthine; Xant, xanthosine; G, guanine; Gr, guanosine; Hx, hypoxanthine.