Table 1.
Summary of additional novel SNPs in some candidate pharmacogenes expressed in the samples from Caucasian residents with northern and western European ancestry from UT, USA.
| Gene | Full name | Additional novel SNPs* | Known SNPs‡ |
|---|---|---|---|
| ADRB1 | Adrenergic, β-1-, receptor | 3 | 2 |
| ADRB2 | Adrenergic, β-2-, receptor, surface | 0 | 8 |
| AHR | Aryl hydrocarbon receptor | 25 | 29 |
| ALOX5 | Arachidonate 5-lipoxygenase | 39 | 107 |
| BRCA1 | Breast cancer 1, early onset | 22 | 65 |
| COMT | Catechol-O-methyltransferase | 8 | 50 |
| CYP2A6 | Cytochrome P450, family 2, subfamily A, polypeptide 6 | 0 | 1 |
| CYP2D6 | Cytochrome P450, family 2, subfamily D, polypeptide 6 | 1 | 1 |
| DRD2 | Dopamine receptor D2 | 36 | 113 |
| GSTP1 | Glutathione S-transferase pi 1 | 2 | 5 |
| KCNJ11 | Potassium inwardly-rectifying channel, subfamily J, member 11 | 1 | 7 |
| MTHFR | 5,10-methylenetetrahydrofolate reductase | 8 | 54 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 7 | 16 |
| P2RY1 | Purinergic receptor P2Y, G-protein coupled, 1 | 1 | 4 |
| SCN5A | Sodium channel, voltage-gated, type V, α-subunit | 56 | 204 |
| SLC19A1 | Solute carrier family 19 (folate transporter), member 1 | 16 | 38 |
| SULT1A1 | Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 5 | 12 |
| TPMT | Thiopurine S-methyltransferase | 23 | 35 |
| TYMS | Thymidylate synthetase | 5 | 42 |
| VDR | Vitamin D receptor | 34 | 111 |
| VKORC1 | Vitamin K epoxide reductase complex, subunit 1 | 1 | 6 |
*
Number of novel SNPs in addition to those known from dbSNP based on the 35 samples from Caucasian residents with northern and western European ancestry from UT, USA in the 1000 Genomes Project (April 2009).
‡
Number of known SNPs based on dbSNP v129.