Fig. 4.
Aβ1–42 oligomers impair recognition memory independently of PrPC. (A) Prnp 0/0 mice given an i.c.v. injection of Aβ oligomers prepared at 4 °C showed significant memory impairment (t 9 = −3,57; **P < 0.01 Student’s t test; VEH n = 5; Aβ1–42 Oligomers n = 6; mean ± SEM). (B) SEC of the 22 °C oligomer preparation (green), initial state (blue). AFM pictures of the oligomeric preparations are shown on the right of the SEC panel (scan size, 2 μm × 2 μm). (C) Oligomeric assemblies prepared at 22 °C significantly affected recognition memory in wild-type mice (Prnp +/+) (t 11 = −2.5; P = 0.03; Student’s t test; VEH n = 6; Aβ1–42 oligomers n = 7) and Prnp 0/0 mice (t 8 = −4.5; P = 0.02; Student’s t test; VEH n = 5; Aβ1–42 oligomers n = 5).