Table 1.
Baseline Variables Classified by End Point
| Variable | Mean (SD) |
P Value | |
|---|---|---|---|
| No Symptomatic Therapya (n=213) |
Symptomatic Therapy Initiatedb (n=200) |
||
| Age, yc | 62.0 (10.7) | 61.3 (10.1) | .77 |
| Education, y | 14.8 (3.3) | 15.7 (3.0) | .01d |
| Time from PD diagnosis, y | 0.7 (0.9) | 0.6 (0.8) | .77 |
| Male sex, % | 60.1 | 68.5 | .12d |
| White race, % | 88.3 | 94.0 | .36 |
| Working full-time, %e | 42.6 | 43.4 | .52 |
| Scale score | |||
| UPDRS III | 14.3 (6.3) | 17.6 (6.8) | <.001d |
| UPDRS I | 1.0 (1.4) | 1.2 (1.3) | .09d |
| UPDRS II | 5.1 (2.9) | 6.9 (3.3) | <.001d |
| UPDRS, total | 20.4 (8.5) | 25.8 (9.1) | <.001d |
| UPDRS I, participant reported | 1.7 (1.7) | 1.6 (1.5) | .97 |
| UPDRS II, participant reported | 5.8 (3.4) | 7.5 (3.8) | <.001d |
| SF-12, Physical Summary | 50.7 (7.4) | 49.3 (7.8) | .01c |
| SF-12, Mental Summary | 51.6 (9.4) | 51.2 (8.7) | .66 |
| Participants with Modified Rankin Scale scores >1, % | 6.6 | 17.0 | <.001d |
| Schwab and England ADL Scale | 94.1 (5.3) | 91.9 (5.1) | <.001d |
| Schwab and England ADL Scale, participant reported | 94.1 (6.5) | 91.9 (6.4) | <.001d |
| TFC | 12.5 (0.9) | 12.2 (1.5) | .01d |
| PDQ-39, Mobility | 8.1 (12.8) | 12.2 (13.9) | <.001d |
| PDQ-39, ADL | 13.1 (14.0) | 19.0 (15.9) | <.001d |
| PDQ-39, Emotional | 19.1 (18.7) | 20.3 (17.5) | .21 |
| PDQ-39, Stigma | 14.1 (18.9) | 17.4 (18.3) | .01d |
| PDQ-39, Social | 8.3 (16.6) | 5.6 (11.8) | .35 |
| PDQ-39, Cognition | 17.0 (17.9) | 17.1 (16.5) | .93 |
| PDQ-39, Communication | 12.3 (18.5) | 14.9 (18.5) | .08d |
| PDQ-39, Discomfort | 26.0 (22.1) | 26.4 (20.5) | .65 |
| PDQ-39, summary index | 14.8 (12.2) | 16.8 (11.1) | .01d |
| GDS | 2.0 (2.4) | 2.3 (2.7) | .11d |
Abbreviations: ADL, activities of daily living; GDS, Geriatric Depression Scale; PD, Parkinson disease; PDQ-39, 39-item Parkinson Disease Questionnaire; SF-12, Medical Outcomes Study Short Form Survey; TFC, Total Functional Capacity Scale; UPDRS, Unified Parkinson Disease Rating Scale.
a
End point not reached.
b
End point reached.
c
Ages older than 89 years were collapsed to 90 years.
d
Variable reaching threshold for inclusion in the multivariable analyses.
e
Measured only in Futility Study 2 (N=200).