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. Author manuscript; available in PMC: 2011 Apr 13.
Published in final edited form as: Cancer Cell. 2010 Apr 13;17(4):348–361. doi: 10.1016/j.ccr.2010.01.022

Figure 2. Linkage of the cancer gene signature to inflammatory and metabolic diseases.

Figure 2

(A) Heat-map representation of the 54 common genes between cancer and sub-categories of metabolic syndrome gene set.

(B) Common central nodes between gene networks derived from differentially expressed genes from MCF10A, BJ fibroblast and Metabolic Syndrome gene sets. Each sphere represents a central node of a gene network. The 24 common nodes are listed.

(C) Comparison of genes and central nodes between the cancer gene signature and gene sets of 32 diseases derived from literature (number of references indicated). For each disease, the number of genes and nodes are indicated along with the overlap with the cancer gene signature and the p-value for the significance of the overlap.

(D) Heat map representation of the relationship between common nodes of cellular transformation and the indicated diseases, with significant relationships indicated in red..