Table 1.
Cohort demographics and numbers. Data from two different research clinics show distinct demographic profiles in the groups. Although some Alzheimer's disease‐type pathology was found in many cases from both clinics, other concomitant neuropathological features including infarcts and Lewy bodies (LBs) were also quite common. Abbreviations: ApoE = apolipoprotein E; MMSE = mini‐mental status examination.
| Research clinic | n | Sex (% F) | Formal education, years | ApoE allele 2/3/4% | Age at death | Final MMSE score | Years since final MMSE | % with infarcts (all types) | % with cortical LBs |
|---|---|---|---|---|---|---|---|---|---|
| Initially normal | 212 | 58 | 16.0 | 8/77/15 | 85.9 | 26.3 | 0.82 | 55.2 | 8.0 |
| (standard deviation) | — | — | ±2.4 | — | ±7.7 | ±5.4 | ±0.6 | — | — |
| Dementia clinic | 122 | 61 | 12.9 | 3/64/33 | 80.8 | 10.4 | 1.55 | 35.2 | 26.2 |
| (standard deviation) | — | — | ±3.1 | — | ±7.0 | ±7.4 | ±1.2 | — | — |
| Combined/total | 334 | 59 | 14.8 | 6/71/23 | 84.0 | 20.4 | 1.09 | 48.0 | 14.7 |