Table 2.
Cumulative power to detect association (α=5×10−8) at a risk allele with frequency 0.20 and 0.40, and allelic odds ratios of 1.1 and 1.2, given sample sizes for the WTCCC, DGI and FUSION studies.
Studies | Risk allele frequency | Allelic odds ratio | Cumulative n cases | Cumulative n controls | power |
---|---|---|---|---|---|
WTCCC | 0.20 | 1.10 | 1924 | 2938 | 0.0002 |
WTCCC+DGI | 0.20 | 1.10 | 3388 | 4405 | 0.0011 |
WTCCC+DGI+FUSION | 0.20 | 1.10 | 4549 | 5579 | 0.0033 |
WTCCC | 0.40 | 1.10 | 1924 | 2938 | 0.0007 |
WTCCC+DGI | 0.40 | 1.10 | 3388 | 4405 | 0.0054 |
WTCCC+DGI+FUSION | 0.40 | 1.10 | 4549 | 5579 | 0.0166 |
WTCCC | 0.20 | 1.20 | 1924 | 2938 | 0.0333 |
WTCCC+DGI | 0.20 | 1.20 | 3388 | 4405 | 0.2078 |
WTCCC+DGI+FUSION | 0.20 | 1.20 | 4549 | 5579 | 0.4426 |
WTCCC | 0.40 | 1.20 | 1924 | 2938 | 0.1336 |
WTCCC+DGI | 0.40 | 1.20 | 3388 | 4405 | 0.5468 |
WTCCC+DGI+FUSION | 0.40 | 1.20 | 4549 | 5579 | 0.8219 |