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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Alzheimers Dement. 2010 Mar;6(2):125–131. doi: 10.1016/j.jalz.2010.01.011

Figure 5. Age of onset curves for individuals with the indicated genotypes using the information available in 1993.

Figure 5

From [1]. Today we propose that each of the age of onset curves is an average of sub-curves. There are two curves for APOE3/4 individuals due to the presence of either a short or a long 523 polymorphisms linked to APOE3. There are likely three curves for APOE3/3 individuals due to the possible combination of alleles at 523, i.e. short/short, short/very long, and very long/very long.