Table 1.
MicroRNAs associated with psychiatric disease
| miRNA | Validated target/Function | Reference |
|---|---|---|
| 16 miRs dysregulated |
Changed in DL-PFC from SCZ patients (microarray) |
(Perkins et al., 2007) |
| let-7g, miR-181b | Changed in temporal gyrus from SCZ patients (microarray) |
(Beveridge et al., 2008) |
| 59 misR dysregulated |
Changed in temporal gyrus from SCZ patients (microarray) |
(Beveridge et al., 2009) |
| 26 miRs dysregulated |
Changed in DL-PFC from SCZ patients (microarray) |
(Beveridge et al., 2009) |
| miR-124, 383, 320, 596, 597, 598 |
Located within chromosome 8 QTL for SCZ, autism |
(Tabares-Seisdedos and Rubenstein, 2009) |
| 5 X-linked miRs | Private mutations in SCZ patients | (Feng et al., 2009) |
| miR-346 | Located in GRID2 intron, reduced in SCZ | (Zhu et al., 2009) |
| miR-34a | GRM7/reduced by both lithium and valproate treatment |
(Zhou et al., 2009) |
| miR-221, 152, 152, 494 |
Changed in BPD lymphocytes after lithium treatment |
(Chen et al., 2009) |
| miR-199a, 128a/b | Upregulated by haloperidol treatment in rats | (Perkins et al., 2007) |
| miR-195, miR-30a | BDNF regulation | (Mellios et al., 2008) |
| miR-96 | HTR1B/aggressive behavior in humans | (Jensen et al., 2009) |
| miR-219 | CAMK2G/reduced by MK-801 treatment in mice | (Kocerha et al., 2009) |