Table 3. Relationship of SNPs at 8 genome-wide significant loci to both blood pressure traits.
For each of eight SNPs, the upper row shows association statistics for the blood pressure trait used for the analysis in which they were selected (SBP or DBP). The lower row (in bold) shows the equivalent association statistics for the alternate blood pressure trait. Results are shown for the 34,433 individuals in the stage 1 Global BPgen GWAS samples.
SNP ID | Chr | Position (NCBI35) | Coded allele | Noncoded allele | Coded allele frequency | N (effective) | Trait | Beta mm Hg | SE | P |
---|---|---|---|---|---|---|---|---|---|---|
rs17367504 | 1 | 11,797,044 | G | A | 0.14 | 34,158 | SBP | −0.79 | 0.18 | 1×10−5 |
DBP | −0.50 | 0.12 | 3×10−5 | |||||||
| ||||||||||
rs11191548 | 10 | 104,836,168 | T | C | 0.91 | 33,123 | SBP | 1.17 | 0.22 | 3×10−7 |
DBP | 0.56 | 0.15 | 2×10−4 | |||||||
| ||||||||||
rs12946454 | 17 | 40,563,647 | T | A | 0.28 | 32,120 | SBP | 0.68 | 0.15 | 4×10−6 |
DBP | 0.34 | 0.09 | 6×10−4 | |||||||
| ||||||||||
rs16998073 | 4 | 81,541,520 | T | A | 0.21 | 26,106 | DBP | 0.65 | 0.11 | 7×10−9 |
SBP | 0.74 | 0.17 | 1×10−5 | |||||||
| ||||||||||
rs1530440 | 10 | 63,194,597 | T | C | 0.19 | 32,718 | DBP | −0.51 | 0.11 | 3×10−6 |
SBP | −0.43 | 0.16 | 7×10−3 | |||||||
| ||||||||||
rs653178 | 12 | 110,470,476 | T | C | 0.53 | 30,853 | DBP | −0.46 | 0.09 | 1×10−7 |
SBP | −0.47 | 0.13 | 3×10−4 | |||||||
| ||||||||||
rs1378942 | 15 | 72,864,420 | C | A | 0.36 | 34,126 | DBP | 0.48 | 0.09 | 6×10−8 |
SBP | 0.62 | 0.13 | 2×10−6 | |||||||
| ||||||||||
rs16948048 | 17 | 44,795,465 | G | A | 0.39 | 34,052 | DBP | 0.40 | 0.09 | 5×10−6 |
SBP | 0.41 | 0.13 | 2×10−3 |