Table 1.
Diagnostic criteria for tuberous sclerosis complex
| Major | Minor |
|---|---|
| Cardiac rhabdomyoma | Multiple pits in dental enamel |
| Cortical tuber | Hamartomatous rectal polyps |
| Facial angiofibroma | Bone cysts |
| Hypomelanotic macule | Radial migration lines in cerebral white matter |
| Lymphangiomyomatosis | Gingival fibromas |
| Renal angiomyolipoma | Retinal achromatic patches |
| Retinal hamartomas | “Confetti” skin lesions |
| Shagreen patch | Multiple renal cysts |
| Subependymal giant-cell tumor | |
| Subependymal nodule | |
| Ungual fibromas |
Definite TSC: Two major or one major plus two minor criteria.
Probable TSC: One major plus one minor criteria.
Possible TSC: One major or two minor features.