Figure 4.
Overlapping Rearrangements in Leukocyte DNA Samples from Two Patients with Bladder Cancer
The plots on the bottom show the mosaic UPDs including almost the entire chromosome 13q found in blood DNA of two bladder cancer patients who also shared deletion-type heterozygous CNVs overlapping ∼833 kb at 13q14 (chr13 coordinates: 49539177–50372054). Analysis of the average LogR of the probes within the CNV yielded below-average LogR ratio for heterozygous deletion values in case 234 (left) and average values in case 962 (right); loss of heterozygosity was also found in case 234, whereas case 962 displayed values compatible with heterozygosity in 1/3 of SNPs within the interval, indicating that the disomic chromosome was the one carrying the CNV in case 234 whereas the other chromosome carried the CNV in case 962. The size of the deletions and overlapping fragment is represented by green bars illustrating their relative location with respect to the chromosome 13 ideogram and showing related genomic features: gene content (including distant RB1 gene), CNVs (Database of Genomic Variants, March 2010 version), and segmental duplications.