Table 2.
Heritability Estimates for Startle Measures
% PPI |
Startle Magnitude |
Initial Startle Reactivity |
% Habituation |
Onset Latency |
Peak Latency |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
30-ms | 60-ms | 120-ms | pulse alone | 30-ms | 60-ms | 120-ms | pulse alone | 30-ms | 60-ms | 120-ms | ||||
n | 163 | 163 | 163 | 198 | 198 | 163 | 186 | 183 | 182 | 168 | 186 | 183 | 182 | 168 |
Heritability | ||||||||||||||
Genetic | ||||||||||||||
Component | 0.19 | 0.45 | 0.33 | 0.67 | 0.54 | 0.31 | 0.90 | 0.70 | 0.39 | 0.63 | 0.68 | 0.29 | 0.42 | 0.68 |
SD | 2.18 | 1.92 | 2.43 | 1.55 | 1.69 | 2.15 | 1.36 | 1.62 | 1.76 | 1.43 | 1.36 | 2.43 | 2.16 | 1.69 |
LR Statistic | 0.91 | 5.41 | 1.80 | 12.22 | 20.25 | 1.96 | 24.81 | 11.90 | 4.22 | 12.41 | 13.60 | 1.50 | 3.54 | 12.53 |
P-value | 0.17 | 0.01 | 0.09 | < 0.001 | < 0.001 | 0.08 | < 0.001 | < 0.001 | 0.02 | < 0.001 | < 0.001 | 0.11 | 0.03 | 0.002 |
Covariates | ||||||||||||||
Age | ||||||||||||||
Beta | 0.01 | −0.01 | 0.003 | −0.02 | −0.02 | 0.001 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.03 | 0.01 | 0.001 |
SD | 0.06 | 0.06 | 0.08 | 0.07 | 0.06 | 0.07 | 0.05 | 0.05 | 0.07 | 0.07 | 0.07 | 0.07 | 0.07 | 0.07 |
Wald Statistic | 2.42 | 1.79 | 0.22 | 11.02 | 11.95 | 0.037 | 7.88 | 23.2 | 5.42 | 2.54 | 6.63 | 10.2 | 4.71 | 0.41 |
P-value | 0.12 | 0.18 | 0.64 | < 0.001 | < 0.001 | 0.97 | 0.005 | < 0.001 | 0.02 | 0.11 | 0.01 | < 0.001 | 0.03 | 0.84 |
Gender | ||||||||||||||
Beta | −0.02 | 0.04 | 0.02 | 0.07 | 0.06 | −0.01 | −0.01 | −0.06 | 0.01 | −0.10 | −0.06 | −0.08 | 0.01 | 0.03 |
SD | 1.28 | 1.15 | 1.15 | 1.13 | 1.13 | 1.15 | 0.95 | 0.95 | 1.08 | 1.04 | 1.09 | 1.08 | 1.08 | 1.17 |
Wald Statistic | 0.06 | 0.17 | 0.05 | 0.77 | 0.57 | 0.03 | 0.01 | 0.77 | 0.01 | 1.38 | 0.57 | 1.03 | 0.03 | 0.11 |
P-value | 0.80 | 0.68 | 0.82 | 0.38 | 0.45 | 0.87 | 0.93 | 0.38 | 0.91 | 0.24 | 0.45 | 0.31 | 0.86 | 0.74 |
Smoking | ||||||||||||||
Beta | −0.22 | 0.05 | −0.05 | −0.10 | −0.15 | −0.24 | 0.10 | 0.10 | 0.15 | 0.10 | −0.26 | −0.05 | 0.09 | −0.36 |
SD | 3.46 | 3.46 | 3.58 | 3.10 | 3.19 | 3.31 | 2.44 | 2.57 | 3.24 | 2.99 | 2.72 | 3.11 | 3.24 | 3.51 |
Wald Statistic | 0.65 | 0.03 | 0.03 | 0.18 | 0.41 | 0.86 | 0.31 | 0.25 | 0.39 | 0.19 | 1.72 | 0.05 | 0.14 | 1.8 |
P-value | 0.42 | 0.86 | 0.86 | 0.67 | 0.52 | 0.35 | 0.58 | 0.62 | 0.53 | 0.66 | 0.19 | 0.83 | 0.71 | 0.18 |
Race | ||||||||||||||
Cauc vs. AA | ||||||||||||||
Beta | 0.17 | −0.06 | −0.41 | 0.63 | 0.52 | −0.44 | −0.89 | −0.81 | −0.55 | −0.61 | −0.62 | −0.50 | −0.57 | −0.43 |
SD | 2.55 | 2.94 | 2.94 | 3.10 | 2.91 | 2.71 | 3.00 | 2.57 | 2.70 | 2.85 | 2.73 | 2.43 | 2.70 | 3.24 |
Wald Statistic | 0.71 | 0.07 | 3.28 | 8.28 | 6.30 | 4.30 | 16.32 | 18.14 | 7.55 | 7.67 | 9.55 | 7.88 | 8.28 | 2.97 |
P-value | 0.40 | 0.79 | 0.07 | 0.004 | 0.01 | 0.04 | < 0.001 | < 0.001 | 0.006 | 0.006 | 0.002 | 0.005 | 0.004 | 0.085 |
Other vs. AA | ||||||||||||||
Beta | −0.14 | −0.21 | −0.40 | 0.29 | 0.24 | −0.44 | −0.61 | −0.53 | −0.29 | −0.40 | −0.78 | −0.09 | −0.55 | −0.14 |
SD | 3.83 | 4.21 | 4.21 | 4.50 | 4.24 | 3.90 | 4.09 | 3.79 | 3.91 | 4.15 | 3.96 | 3.79 | 4.05 | 4.67 |
Wald Statistic | 0.22 | 0.39 | 1.50 | 0.84 | 0.64 | 2.07 | 4.22 | 3.55 | 0.99 | 1.57 | 7.23 | 0.1 | 3.3 | 0.15 |
P-value | 0.64 | 0.53 | 0.22 | 0.36 | 0.42 | 0.15 | 0.04 | 0.06 | 0.32 | 0.21 | 0.01 | 0.75 | 0.07 | 0.70 |