Table 1.
Mechanisms of nuclear transport involving membrane-bound trafficking
| MW (kDa) | ‘INTERNET’ | ER localization | Importins involvement | Endocytosis | Reference | |
|---|---|---|---|---|---|---|
| RTKs/EGFR/ErB-2 | 170/185 | ? | + | + | + | Lo and Hung (2006); Giri et al. (2005) |
| RTKs/FGFR-1 | 120,145 | − | + | + | Reilly and Maher (2001) | |
| INM proteins | >40 | + | + | + | − | King et al. (2006); Saksena et al. (2006) |
| Ligands/HB-EGF | 20–30 | + | + | Hieda et al. (2008) |
Abbreviations: EGFR, epidermal growth factor receptor; ER, endoplasmic reticulum; FGFR, fibroblast growth factor receptor; HB-EGF, heparin-binding epidermal growth factor; INM, inner nuclear membrane; INTERNET, integral trafficking from the endoplasmic reticulum to the nuclear envelope transport; MW, molecular weight; RTK, receptor tyrosine kinase.