TABLE 1.
Effects of 48 h in vivo 3α,5β-THP administration on mIPSC characteristics of pyramidal cells in CA1 hippocampus
| Control | 48 h of 3α,5β-THP | |
|---|---|---|
| 10–90% Rise time (ms) | 0.85 ± 0.04 | 0.78 ± 0.12 |
| τw (35°) | 3.42 ± 0.45 | 2.66 ± 0.32* |
| τw (27°) | 11.6 ± 2.1 | 8.23 ± 1.65* |
| Monoexponential τ (ms) | 3.3 ± 0.63 | 2.84 ± 0.46 |
| Biexponential τfast (ms) | 0.9 ± 0.16 | 0.5 ± 0.12* |
| (%) | (38 ± 6.7) | (58 ± 11.1) |
| τslow (ms) | 5.2 ± 0.5 | 5.0 ± 1.2 |
| Percent of mIPSCs with a biexponential decay | 10 | 38* |
| mIPSC frequency (Hz) | 12.5 ± 4.5 | 11.2 ± 3.1 |
Unless otherwise indicated, recordings were carried out at 35°C (n = 1,800/group, 35°C; n = 2,000/group, 27°C; representative of 80–100 mIPSCs/ cell, 20–25 cells/group, 6–10 animals/group.)
*
P < 0.05 vs. control values.