. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Heart Rhythm. 2010 Feb 1;7(6):771–778. doi: 10.1016/j.hrthm.2010.01.032

Table 1.

Voltage-dependent gating parameters of β3-WT and β3-V36M

	Peak I_Na		Activation			Inactivation		Recovery
Samples	pA/pF	n	V_1/2(mV)	K	n	V_1/2 (mV)	n	τ_f (ms)	τs (ms)	As (%)	n
SCN5A + Vector	−230 ± 49	13	−36 ± 2	4.7	7	−75 ± 1	8	1.5 ± 0.3	54 ± 9	25 ± 2	8
SCN5A + β3-WT	−245 ± 43	26	−39 ± 1	4.7	20	−79 ± 1^#	21	1.4 ± 0.2	44 ± 7	24 ± 2	14
SCN5A + β3-V36M	−102±24^*^#	13	−36 ± 2	5.0	11	−80 ± 1^#	11	1.5 ± 0.2	43 ± 9	28 ± 1	9

The fitted values of voltage-dependent gating parameters represent the mean ± SEM for number of cells n in the table. These parameters were obtained from fitting the individual experiments as in Figure 2C&D to the appropriate model equations.

For the Boltzmann fits the parameters of V_1/2 are the midpoint of activation and inactivation.

P< 0.05 vs SCN5A + Vector.

P< 0.05 vs β3-WT.