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Double-blind, randomized, placebo-controlled trials of NSAIDs in patients with MCI.
| Drug | Treatment duration | Dose (mg/day) | No. patients | Main outcome | Reference |
|---|---|---|---|---|---|
| Rofecoxib | 4 years | 25 | 1,457 | Detrimental effects | Thal et al. (2005) |
| Triflusal | 13 months | 900 | 257 | Neutral/beneficial effects | Gómez-Isla et al. (2008) |
| Celecoxib | 18 months | 200–400 | 88* | Beneficial effects | Small et al. (2008) |
*Subjects with age-associated memory decline.
