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. 2010 Jul 29;341:c3691. doi: 10.1136/bmj.c3691

Table 3.

 Number of people with cardiovascular events and deaths by treatment allocation

Studies Calcium group Placebo group
No of participants Myocardial infarction Stroke Composite* Death No of participants Myocardial infarction Stroke Composite* Death
Dawson-Hughes19† 238 0 0 NA NA 123 0 1 NA NA
Reid21 22 68 0 2 2 0 67 0 1 1 0
Riggs24‡ 119 0 0 0 1 117 0 0 0 0
Baron25 464 20 15 31 25 466 17 11 28 22
Bonithon-Kopp27§ 204 0 1 1 8 212 0 0 1 9
Grant28 1311 45 56 97 238 1332 39 48 86 217
Grant28** 1306 44 60 100 220 1343 34 58 89 218
Reid15 16 732 31 34 60 34 739 21 25 50 29
Prince29†† 730 21 38 56 29 730 17 40 56 38
Bonnick30‡‡ 282 0 1 NA 2 281 0 2 NA 1
Lappe31 32†† 446 2 5 8 NA 288 2 4 8 NA
Reid33 216 3 0 3 2 107 0 0 0 1
Total 6116 166 212 358 559 5805 130 190 319 535

NA=not available.

*Any of myocardial infarction, stroke, or sudden death. Seventeen events were classified as sudden deaths that occurred in eight people allocated to calcium and nine allocated to placebo.

†Unpublished trial level data provided by author. Data on stroke available only for participants who withdrew from study.

‡Unpublished trial level data provided by author. Data available only for participants who withdrew from study.

§Unpublished trial level data provided by author. Data on cause of death only.

¶Calcium versus placebo arms in Randomised Evaluation of Calcium or Vitamin D (RECORD) study.

**Calcium and vitamin D versus placebo plus vitamin D arms in Randomised Evaluation of Calcium or Vitamin D (RECORD) study.

††Unpublished trial level data provided by author.

‡‡Unpublished trial level data provided by Boyd Scott.