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. 2010 Jul 13;103(3):354–361. doi: 10.1038/sj.bjc.6605793

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Copyright © 2010 Cancer Research UK

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Effects of TS depletion on cell cycle distribution and on cyclin E and c-Myc expression in lung cancer cells. (A) The indicated cell lines were transfected with nonspecific (NS) or TS-1 siRNAs for 48 or 72 h and were then fixed, stained with propidium iodide, and analysed for cell cycle distribution by flow cytometry. Data are means±s.d. of triplicates from experiments that were repeated on two additional occasions with similar results. (B) Cells were transfected with NS or TS-1 siRNAs for 72 h, after which cell lysates were prepared and subjected to immunoblot analysis with antibodies to TS, cyclin E, c-Myc, and β-actin. Transfection with the NS siRNA had no substantial effect on cell cycle distribution or on the expression of cyclin E or c-Myc compared with untreated cells.