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. 2010 Aug 9;190(3):407–425. doi: 10.1083/jcb.200911020

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© 2010 Velichkova et al.

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Figure 1. — mtm promotes remodeling of cell shape. (A and B) Microtubules in Drosophila Kc₁₆₇ cells reveal normal round (A) and bipolar (B)-shaped cells 1 d after ecdysone. (B’) mtm RNAi inhibited ecdysone-induced cell elongation. (C) RNAi depletion of mtm transcript and Mtm-GFP (anti-GFP). WB, Western blot. (D) Cell numbers 1–4 d after RNAi. (E) Normal morphology of mtm-depleted cells in absence of ecdysone. (E and F) Latrunculin B (+LatB) destabilized F-actin (red) and permitted microtubule protrusions (green) in untreated (E) and ecdysone-treated (F) mtm RNAi cells. (G, right) GFP:Mtm induced cell elongation in absence of ecdysone. (left) GFP cells remained round. Percentage of transfected round or bipolar-shaped cells. Error bars indicate mean ± SD.