Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Aug 9;190(3):407–425. doi: 10.1083/jcb.200911020

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 Velichkova et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — mtm promotes hemocyte protrusions and essential roles in Drosophila. (A) Larval lethal mtm mutant alleles: z2-4747 mutation in CX₅R catalytic motif, Δ77 and Δ210 deletions, and UAS-IRmtm RNAi hairpins. (B) Percentage of lethal progeny for mtm alleles or hemocyte-targeted RNAi (PxnGAL4; CgGAL4) rescued to viability with mtm or human MTMR2 cDNA. (C–F) F-actin in primary hemocytes (top) and zoom of cell edges (bottom). (C) Normal radial protrusions in mtmΔ77/+. (D and E) Lack of protrusions in mtm^Δ77/mtm^z2-4747 and hemocyte mtm RNAi. (F) Increased number of protrusions in mtm overexpression. (G) Percentage of hemocytes with normal, no, or ectopic protrusions. (H, right) Lack of hemocyte protrusions with 1-d induced mtm RNAi (18 to 29°C shift). IR-mtm/+; Pxn-GAL4/+. (I) SCAR protein in control (top) and enriched along cell cortex in mtm-depleted hemocytes (bottom, arrowheads; Cg-GAL4/IRmtm). Boxed areas are shown at magnified views in the panels below.