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. Author manuscript; available in PMC: 2010 Aug 17.
Published in final edited form as: Science. 2010 Jul 30;329(5991):533–538. doi: 10.1126/science.1188308

Table 1.

Trends in expression levels and protein localization. Table of Z scores of subsets of gene classes characterized by protein and RNA mean, RNA lifetime, a, b, ratio of fluorescence detected on the edge compared to inside of the cell (E/I), and the degree of punctuate protein localization (DP). Leading strand corresponds to transcription in the same direction as the replication fork. PPI indicates protein-protein interactions. Z scores of more than 3 (indicated by red) represent a significantly larger value compared with the whole genome distribution with >99.9% confidence, while Z scores less than -3 (indicated by blue) represent a significantly smaller value.

Category n Protein RNA


Mean a b E/I DP Mean Lifetime
All 1018 0.00 0.00 0.00 0.00 0.00 0.00 0.00

Essential gene 121 7.54 8.70 5.34 -2.19 -3.16 5.61 1.38
Nonessential gene 894 -2.74 -3.16 -2.02 0.74 1.30 -1.99 -0.32

Enzyme 410 3.98 4.28 1.85 -5.45 -3.04 3.30 3.15
Translation 17 4.04 3.36 3.30 -0.86 -3.52 3.30 -2.44
Turnover, degradation 13 3.05 3.60 2.08 -0.99 -1.76 2.37 2.14
Transcription factor 98 0.61 1.27 0.71 -2.95 4.29 -0.53 -2.53
Transporter 88 -0.84 0.45 -1.44 7.78 0.96 2.28 3.29

Lagging strand 425 -1.42 -1.95 -0.82 0.74 -0.07 -4.42 -3.63
Leading strand 593 1.12 1.62 0.61 -0.64 0.02 3.96 3.17

Gene length < 500 bp 193 4.06 1.09 3.34 -1.06 -2.98 2.67 -1.65
Gene length >= 500 bp 825 -1.92 -0.55 -1.72 0.57 1.45 -1.26 0.73

Known PPI 603 3.73 3.75 1.37 -3.69 -3.77 1.90 0.58
No known PPI 415 -4.68 -4.65 -1.73 4.28 4.43 -2.25 -0.61