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. 2010 Jun 15;38(15):e157. doi: 10.1093/nar/gkq548

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Demonstration of FACADE performance on a complex cancer genome. Displayed are the segmentation results from FACADE, DNACopy with CGHCall and GLAD, applied to an Agilent 244K profile of the BT474 cell line (displayed as the Log₂ signal ratio of BT474 versus Reference). Shading and colored lines indicate regions detected as copy number gain (red) and loss (green) by each algorithm. The results for chromosome 11 (A) clearly demonstrate the similarity in overall segmentation results between all three algorithms, with a slight reduction in deletion detection in GLAD, and increase sensitivity to low level gains in FACADE. This can be clearly seen in the zoomed view of 11p12 to 11q13 (B) where a low level gain (indicated by an arrow) is clearly detected by only FACADE.