Figure 8.
l-Dopa reduces functional connectivity within the default mode network. The iterative connectivity analysis, which examined the FC of the PCC region that demonstrated reduced connectivity with the right hemisphere probability-weighted caudate ROI (seed location shown on left of figure). The figure displays the thresholded Z-score maps of positive functional connectivity for each condition, and significant l-dopa-related increases and decreases in functional connectivity for this PCC seed ROI. A significant reduction in the connectivity of the default mode network in the l-dopa condition, relative to placebo, was observed. Images are displayed according to radiological convention (left is right).