. 2010 Aug 2;107(33):14817–14822. doi: 10.1073/pnas.1009164107

Table 1.

Neural activity during social exclusion (vs. inclusion) that was significantly associated with greater inflammatory responses to the Trier Social Stress Test (TSST), as indexed by changes in levels of a soluble receptor for tumor necrosis factor-α (sTNFαRII) (n = 31)

Brain region	Brodmann area	MNI coordinates	Cluster size (k)	t	r (TNF)
Paralimbic
dACC	BA 24	−6 18 34	351	4.58	0.67
dACC	BA 24	12 38 0	29	4.45	0.63
Anterior insula		−34 –22 28	45	4.44	0.63
Parahippocampal gyrus	BA 36	−22 –20 −30	31	4.13	0.60
Cortex
Middle frontal gyrus	BA 10/46	−30 52 12	99	4.54	0.64
Inferior frontal gyrus	BA 45	50 26 20	23	3.80	0.59
Precuneus	BA 30	4 –46 −4	454	6.08	0.71
Fusiform gyrus	BA 37	−40 –60 −12	28	4.41	0.63
Lingual gyrus	BA 18	26 –74 0	296	6.33	0.71
Lingual gyrus	BA 18	−4 –70 −8	107	4.36	0.63
Fusiform gyrus	BA 18	22 –98 −10	21	3.75	0.58
Subcortical and cerebellum
Caudate		18 18 14	79	4.34	0.61
Thalamus		−20 –28 14	51	4.30	0.62
Midbrain (substantia nigra)		−12 –12 −12	20	4.16	0.62
Medulla		6 –32 −48	30	4.09	0.61
Cerebellum		32 –48 −36	49	4.41	0.64
Cerebellum		−4 –70 −34	35	4.23	0.62
Cerebellum		−28 –44 −24	21	4.05	0.60
Cerebellum		−22 –72 −34	45	4.00	0.59

The brain regions listed represent those that were significantly related to TSST-induced changes in sTNFαRII, thresholded at P < 0.001, 20 voxels. dACC is the dorsal anterior cingulate cortex; BA refers to putative Brodmann's area; MNI coordinates identify the local maxima of particular brain activations, reported in Montreal Neurological Institute (MNI) format; Cluster size (k) is the number of voxels in each activation cluster that was significantly associated with greater sTNFαRII responses to the TSST; t is the t-value at those coordinates (local maxima); r (TNF) is the correlation coefficient describing the strength of association between the activation cluster and sTNFαRII response to the TSST.