Table 2.
A Survey of EC50 Values for the Potency of NO in sGC Activation
| Reference | EC50 (nM) | Method |
|---|---|---|
| Stone and Marletta (1996) (95) | 250 | In vitro; interaction of NO with purified sGC |
| Russwurm et al. (1998) (83) | 690 | In vitro; interaction of NO with purified sGC |
| Bellamy et al. (2000) (9) | 20 | In vitro; interaction of NO with purified sGC in cerebellar cells |
| Artz et al. (2001) (5) | 1,600 | In vitro; interaction of NO with purified sGC |
| Condorelli and George (2001) (23) | 23 | In silico; computational simulation of the kinetics of sGC activation by NO |
| Bellamy et al. (2002) (8) | 3.9 | In vitro; interaction of NO with sGC in brain tissue |
| Roy and Garthwaite (2006) (82) | 10 | In vitro; interaction of NO with sGC in cerebellar cells and platelets |
| Rodriguez-Juarez (2007) (81) | 2.9 | In vitro; interaction of NO with sGC in tetracycline-inducible HEK-293 cells |
| Yan et al. (2007) (112) | 9.7 | Ex vivo; apparent vasorelaxation of rat thoracic aorta in phosphate buffer |