TABLE 2.
SECRETION OF CYTOKINES AND VEGF BY NRF2 WILD-TYPE AND NRF2-DEFICIENT BONE MARROW–DERIVED DENDRITIC CELLS AT BASELINE
| DC phenotypes | IL-6 | IL-12 | IL-18 | TNF-α | VEGF |
|---|---|---|---|---|---|
| Nrf2+/+ | 128 (17) | 619 (106) | 438 (31) | 104 (15) | 559 (186) |
| Nrf2−/− | 354 (22) | 1,293 (125) | 183 (19) | 296 (13) | 1,109 (54) |
| P value† | <0.001 | 0.003 | 0.001 | <0.001 | <0.001 |
Definition of abbreviation: DC, dendritic cell; VEGF, vascular endothelial growth factor.
Values are in pg/million cells of secreted cytokine. Results are from six independent experiments. n = 6 mice per genotype. P values were calculated using the paired Student's t test.