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Arx-deficient mice lack glucagon-producing cells. A, C, and E, Immunostaining of glucagon, insulin, and somatostatin in 3- to 6-month-old control and Arx-deficient pancreas. Morphometric analysis indicated 99% reduction in the α-cell mass (B), 1.5-fold increase in the β-cell mass (D), and 2-fold increase in the δ-cell mass (F) in the Arx-deficient animals. Values are mean ± sem from three mice per group. *, P < 0.05 between genotypes.
