Table 2.

Kidney Function and WMHV

	Parameter Estimate (95% CI)	P
Trichotomized CCl
Unadjusted
CCl 15–60 mL/min	0.748 (0.525–0.971)	<0.001
CCl 60–90 mL/min	0.357 (0.203–0.511)	<0.001
CCl >90 mL/min	Ref
Model 1^*
CCl 15–60 mL/min	0.262 (0.036–0.489)	0.023
CCl 60–90 mL/min	0.116 (−0.033–0.265)	0.127
CCl >90 mL/min	Ref
Model 2^†
CCl 15–60 mL/min	0.322 (0.095–0.550)	0.005
CCl 60–90 mL/min	0.152 (0.004–0.301)	0.044
CCl >90 mL/min	Ref
Trichotomized eGFR
Univariate
eGFR 15–60 mL/min	0.494 (0.229–0.759)	<0.001
eGFR 60–90 mL/min	0.176 (0.021–0.330)	0.026
eGFR >90 mL/min	Ref
Model 1^*
eGFR 15–60 mL/min	0.322 (0.080–0.564)	0.009
eGFR 60–90 mL/min	0.027 (−0.117-0.171)	0.711
eGFR >90 mL/min	Ref
Model 2^†
eGFR 15–60 mL/min	0.275 (0.028–0.521)	0.029
eGFR 60–90 mL/min	0.027 (−0.117-0.171)	0.710
eGFR >90 mL/min	Ref
Continuous serum creatinine (per 1 mg/dL increase)
Univariate	1.482 (1.089–2.017)	0.012
Model 1^*	1.527 (1.108–2.105)	0.010
Model 2^†	1.479 (1.067–2.050)	0.019

Model 1: adjusted for age, gender, race– ethnicity, and high school education.

^†

Model 2: model 1, hypertension, diabetes, cardiac disease, tHcy.