Table 1.
Numbers of differentially methylated regions (DMRs) identified in myeloid versus lymphoid commitment
Comparisons (Group 1 vs. Group 2) | Numbers of DMRsa |
DMRs within 2 kb of a transcriptional start site | Locations of DMRs relative to CpG islands (%) |
|||
---|---|---|---|---|---|---|
Group 1>Group 2 | Group 1<Group 2 | Islands | Shoresc | >2 kbc | ||
MPPFL− vs. MPPFL+ | 18 | 112 | 69 | 56.1 | 35.4 | 8.5 |
MPPFL+ vs. CLP | 302 | 46 | 182 | 52.4 | 39.0 | 8.6 |
CLP vs. DN1 | 203 | 3017 | 2433 | 17.8 | 80.7 | 1.5 |
DN1 vs. DN2 | 3923 | 174 | 3125 | 18.9 | 80.3 | 0.7 |
DN2 vs. DN3 | 47 | 12 | 13 | 5.0 | 78.3 | 16.7 |
MPPFL+ vs. CMP | 149 | 1412 | 1129 | 17.3 | 81.2 | 1.5 |
CMP vs. GMP | 768 | 11 | 554 | 16.8 | 81.1 | 2.1 |
DN1 vs. GMP | 1011 | 122 | 773 | 16.8 | 78.2 | 5.0 |
Area cutoff of 2.0 was used to calculate the number of DMRs (see online Methods).
Shores were defined for this table as overlapping islands by <50% and/or extending up to 2 kb from an island.
Regions 2 kb from an island.