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. Author manuscript; available in PMC: 2010 Oct 19.
Published in final edited form as: Circ Res. 2010 Jun 24;107(4):476–484. doi: 10.1161/CIRCRESAHA.109.215020

Figure 6. PHLPP-1 knockdown potentiates H2O2-induced Akt activation and attenuates H2O2-induced apoptosis.

Figure 6

NRVMs were treated with 150 μmol/L H2O2. A, Potentiation of phosphorylation of Akt (Ser473). B, Quantitative analysis of H2O2-induced phosphorylation of Akt at S473. *P<0.05, **P<0.01 vs control. C, Cardiomyocytes were cultured for 20 hours in the presence or absence of 150 μmol/L H2O2±LIF. Akt inhibitor III (SH-6) (2 μmol/L) or Akt inhibitor V (triciribine) (1 μmol/L) were added before LIF treatment. DNA fragmentation was determined by an ELISA-based assay (n=4 to 9). **P<0.01.