Table 5.

Blood and Brain ¹³C-Glucose Enrichments and Brain ¹³C-Glucose-6-Phosphate Concentrations

	Saline	Ethanol	Acetate
Blood ¹³C/¹²C-glucose enrichments^a	0.448 ± 0.023	0.426 ± 0.008	0.360 ± 0.051
Brain ¹³C/¹²C-glucose enrichments^a	0.461 ± 0.059	0.367 ± 0.008	0.295 ± 0.048
Δ (percent difference in blood-brain enrichments)^b	2.8 ± 1.1	−16.4 ± 3.5^a	−27.3 ± 7.7^d
Brain ¹³C-glucose-6-phosphate^c	0.091 ± 0.013	0.070 ± 0.016	0.066 ± 0.007^e

Animals infused with solutions of phosphate buffered saline (PBS) (n = 5), 4 M ethanol in PBS (n = 8), or 2 M sodium acetate in PBS (n = 6). Infusates contained 1.8 mg/ml of ¹³C-2-glucose as tracer.

Values are glucose ¹³C/¹²C enrichments ± SEM.

$Δ = {\frac{\frac{{}^{13}C}{{}^{12}C} {glucose}_{blood} - \frac{{}^{13}C}{{}^{12}C} {glucose}_{brain}}{\frac{{}^{13}C}{{}^{12}C} {glucose}_{blood}}} \times 100$

Values are means in μmole/g wet weight ± SEM.

p < 0.01 between ethanol- or acetate-infused animals and saline, paired t-test with Bonferroni adjustment for multiple group comparisons.

p < 0.03 between acetate-infused animals and saline controls, ANOVA.