TABLE 1.
AU-rich element motifs located within the 3′ UTRs of the downregulated genesa
| GenBank accession no. | Gene product | No. of instances of indicated motif |
||||
|---|---|---|---|---|---|---|
| AUUUA | UUAUUUAUU | UUAUUUAWW | UAUUUAU | UA[U]2-5AU | ||
| NM_001634 | AMD1 | 6 | 0 | 0 | 1 | 2 |
| NM_181847 | AMIGO2 | 7 | 0 | 0 | 0 | 1 |
| NM_004282 | BAG2 | 4 | 0 | 0 | 0 | 0 |
| NM_001709 | BDNF | 9 | 0 | 0 | 3 | 5 |
| NM_001165 | BIRC3 | 4 | 1 | 1 | 2 | 3 |
| NM_001048249 | C5orf43 | 9 | 0 | 0 | 0 | 2 |
| NM_002982 | CCL2 | 1 | 0 | 0 | 0 | 3 |
| NM_053056 | CCND1 | 7 | 0 | 0 | 1 | 6 |
| NM_002090 | CXCL3 | 7 | 1 | 3 | 3 | 3 |
| NM_000104 | CYP1B1 | 10 | 0 | 2 | 2 | 6 |
| NM_000788 | DCK | 4 | 0 | 0 | 0 | 2 |
| NM_013989 | DIO2 | 11 | 1 | 1 | 4 | 8 |
| NM_012242 | DKK1 | 3 | 0 | 0 | 0 | 0 |
| NM_004414 | DSCR1 | 2 | 0 | 0 | 0 | 1 |
| NM_001955 | EDN1 | 4 | 0 | 0 | 1 | 1 |
| NM_001993 | F3 | 3 | 0 | 1 | 1 | 3 |
| NM_002006 | FGF2 | 18 | 0 | 0 | 1 | 11 |
| NM_006350 | FST | 1 | 0 | 0 | 0 | 0 |
| NM_015714 | G0S2 | 0 | 0 | 0 | 0 | 1 |
| NM_002041 | GABPB2 | 1 | 0 | 0 | 1 | 1 |
| NM_002053 | GBP1 | 4 | 0 | 0 | 1 | 2 |
| NM_018284 | GBP3 | 2 | 0 | 0 | 0 | 0 |
| NM_006851 | GLIPR1 | 10 | 0 | 0 | 1 | 4 |
| NM_006143 | GPR19 | 1 | 0 | 0 | 0 | 0 |
| NM_000830 | GRIK1 | 0 | 0 | 0 | 0 | 0 |
| NM_000599 | IGFBP5 | 7 | 0 | 1 | 2 | 2 |
| NM_002185 | IL7R | 2 | 0 | 0 | 0 | 0 |
| NM_022767 | ISG20L1 | 3 | 1 | 1 | 2 | 2 |
| NM_032860 | LTV1 | 0 | 0 | 0 | 0 | 3 |
| NM_005911 | MAT2A | 3 | 1 | 1 | 1 | 2 |
| NM_002422 | MMP3 | 1 | 0 | 1 | 0 | 1 |
| NM_014903 | NAV3 | 5 | 1 | 1 | 1 | 4 |
| NM_181782 | NCOA7 | 12 | 1 | 1 | 3 | 8 |
| NM_018983 | NOLA1 | 0 | 0 | 0 | 0 | 0 |
| NM_002527 | NTF3 | 1 | 1 | 1 | 1 | 2 |
| NM_013248 | NXT1 | 1 | 0 | 0 | 0 | 0 |
| NM_017906 | PAK1IP1 | 0 | 0 | 0 | 0 | 0 |
| NM_002658 | PLAU | 2 | 0 | 1 | 2 | 4 |
| NM_006622 | PLK2 | 2 | 1 | 1 | 2 | 3 |
| NM_005729 | PPIF | 2 | 0 | 0 | 0 | 0 |
| NM_016077 | PTRH2 | 0 | 0 | 0 | 0 | 0 |
| NM_002852 | PTX3 | 2 | 0 | 0 | 1 | 2 |
| NM_003702 | RGS20 | 3 | 0 | 0 | 1 | 3 |
| NM_006745 | SC4MOL | 3 | 0 | 0 | 0 | 0 |
| NM_003020 | SCG5 | 0 | 0 | 0 | 0 | 0 |
| NM_003017 | SFRS3 | 3 | 0 | 0 | 0 | 1 |
| NM_003714 | STC2 | 12 | 0 | 1 | 3 | 4 |
| NM_002546 | TNFRSF11B | 3 | 0 | 1 | 1 | 4 |
| NM_006470 | TRIM16 | 0 | 0 | 0 | 0 | 0 |
| NM_033035 | TSLP | 7 | 0 | 0 | 0 | 3 |
a
An R script was used to identify the number of ARE motifs located within the 3′ UTRs of 50 genes that were downregulated following inhibition of PI 3-kinase.