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. 2009 Oct 14;18(9):1039–1043. doi: 10.1038/ejhg.2009.177

Table 2. Prediction of the heritability of liability (hL2) and proportion of sporadic cases in human complex diseases.

          P(sporadic I) (%) P(sporadic II) (%)
Disease K (%) λ1 hL2 (%) Sa Theor.b Simu.c Theor.b Simu.c
Prostate cancer27 2.40 2.8 44 2 81 82 63 66
        3 76 78 49 55
Colon cancer27 1.50 5.1 64 2 79 80 64 67
        3 73 76 51 58
Breast cancer27 3.60 2.5 44 2 75 77 53 57
        3 69 72 37 45
Lung cancer27 1.70 6.1 76 2 72 74 55 61
        3 65 69 41 51
Stomach cancer27 1.00 6.0 63 2 83 84 71 74
        3 78 80 60 65
Bladder Cancer27 1.00 1.7 16 2 95 95 88 88
        3 93 93 81 82
Schizophrenia28, 29 1.00 8.6 80 2 76 78 63 67
        3 70 74 51 59
Schizophrenia22 0.40 9.0 63 2 90 90 83 85
        3 86 88 76 79
Bipolar disorder30 1.00 6.8 69 2 81 82 69 72
        3 75 78 57 64
Bipolar disorder22 0.45 7.9 60 2 90 90 83 84
        3 87 88 76 79
Unipolar disorder31 10.0 1.7 39 2 60 57 31 25
        3 52 47 18 11
Type I diabetes32 0.54 13.7 86 2 81 79 73 69
        3 77 73 66 59
Type II diabetes33 3.00 3.5 60 2 72 73 50 55
        3 64 68 35 44
Crohn's disease1 0.10 26 76 2 92 93 89 90
        3 90 91 85 87
Asthma34 2.00 2.6 38 2 85 86 70 72
        3 81 82 57 62
Coronary artery disease35 5.60 3.2 72 2 55 59 29 38
        3 45 53 15 26
Systemic lupus erythematosus36 0.03 30 65 2 97 97 96 96
        3 96 96 95 95
Rheumatoid arthritis16 0.75 8.0 70 2 83 84 73 75
        3 78 80 62 68

The disease prevalence (K) and first-degree recurrence risk (λ1) are obtained from the literature and may include averaging over sexes. hL2 is calculated from its analytical relationship with K and λ1 (Appendix).

a

S is the mean family size per couple.

b

Theor. represents the predictions of P(sporadic) by analytical approximation.

c

Simu. represents the predictions of P(sporadic) by simulation.