TABLE 1.
Clinical and biological characteristics of obese subjects before, and 3 and 6 months after gastric surgery
| After bypass |
|||
|---|---|---|---|
| Before bypass | 3 months | 6 months | |
| Food intake | |||
| Food intake (kcal) | 1,933 ± 101A | 1,080 ± 87B | 1,355 ± 54C |
| Adiposity markers | |||
| Body weight (kg) | 126 ± 4.2A | 107 ± 3.9B | 98 ± 3.8C |
| BMI (kg/m2) | 47.6 ± 1.5A | 40.6 ± 1.3B | 37.1 ± 1.3C |
| Adipocyte diameter (μm) | 116.7 ± 1.5A | 110.7 ± 1.0B | 103.3 ± 3.2C |
| REE (kcal) | 1,814.4 ± 54.8A | 1,842.5 ± 53.6A | 1,551.1 ± 42.9B |
| Fat mass % | 47.9 ± 1.0A | 44.5 ± 1.0B | 41.3 ± 1.2C |
| Fat-free mass % | 50.0 ± 1.0A | 53.0 ± 0.9B | 55.9 ± 1.1C |
| Leptin (ng/ml) | 50.8 ± 3.7A | 25.6 ± 2.5B | 24.9 ± 2.8B |
| Plasma glucose homeostasis and insulin sensitivity | |||
| Glycemia (mmol/l) | 6.4 ± 0.5A | 5.1 ± 0.2B | 4.8 ± 0.1B |
| A1C (%) | 6.4 ± 0.3A | 5.7 ± 0.1B | 5.8 ± 0.1B |
| Insulinemia (μU/ml) | 17.1 ± 1.6A | 10.7 ± 0.9B | 6.9 ± 0.7C |
| HOMA-IR | 0.88 ± 0.09A | 0.63 ± 0.03B | 0.78 ± 0.09A |
| Adiponectin (μg/ml) | 6.4 ± 0.5A | 7.8 ± 0.7A | 8.3 ± 0.7B |
| Plasma lipid homeostasis | |||
| Total cholesterol (mmol/l) | 4.54 ± 0.16A | 4.23 ± 0.16A | 4.34 ± 0.15A |
| Triglycerides (mmol/l) | 1.57 ± 0.19A | 1.54 ± 0.17A | 1.48 ± 0.17A |
| HDL cholesterol (mmol/l) | 1.22 ± 0.05A | 1.17 ± 0.06A | 1.30 ± 0.06B |
| Inflammatory markers | |||
| Plasma hs-CRP (mg/dl) | 3.1 ± 0.8A | 2.5 ± 0.9B | 2.7 ± 0.8B |
| Plasma IL-6 (pg/ml) | 4.4 ± 0.4A | 4.2 ± 0.4A | 3.4 ± 0.4A |
| Plasma orosomucoid (g/l) | 1.02 ± 0.04A,B | 0.94 ± 0.04A | 0.86 ± 0.03B |
Values are expressed as mean ± SE (n = 30). Fat mass %, fat-free mass %: values expressed as a percentage of body weight. Paired Wilcoxon stands for analyzing parameters changes between various time points. Data not sharing the same letter within a horizontal line are significantly different (P < 0.05). REE: resting energy expenditure.